Document Detail

Effect of pinealectomy and of diabetes on liver insulin and glucagon receptor concentrations in the rat.
MedLine Citation:
PMID:  2543806     Owner:  NLM     Status:  MEDLINE    
The studies described in this paper were undertaken to characterize the circulating and hepatic insulin and glucagon receptor concentrations of control (C), diabetic (Db), and pinealectomized-diabetic (Pn + Db) rats. Compared with C rats, an increase in plasma glucose and glucagon levels and a reduction in circulating insulin concentrations in Db animals was observed; these differences were greater in Pn + Db rats. In liver membranes, insulin binding was lower in Db and in Pn + Db than in C rats, and glucagon binding was greater in Db and in Pn + Db than in C rats. The modifications in hormone binding did not reflect changes in the affinity constants. The time courses of hormone association and dissociation from liver membranes were similar in all three experimental groups. The degradation of both hormones and their receptors was similar in all three groups. These findings indicate that in either pinealectomized-diabetic or diabetic rats there were significant changes in the circulating and liver insulin and glucagon receptor concentrations and that the changes in the circulating levels of both pancreatic hormones were more pronounced in pinealectomized-diabetic animals. In addition, the absence in Db and in Pn + Db rats of the insulin and glucagon down-regulation of their own receptors could further modify metabolic activities in these animals.
C Mellado; V Rodríguez; J G de Diego; E Alvarez; E Blázquez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pineal research     Volume:  6     ISSN:  0742-3098     ISO Abbreviation:  J. Pineal Res.     Publication Date:  1989  
Date Detail:
Created Date:  1989-07-27     Completed Date:  1989-07-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8504412     Medline TA:  J Pineal Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  295-306     Citation Subset:  IM    
Departamento de Bioquímica, Universidad de Salamanca, Madrid, Spain.
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MeSH Terms
Blood Glucose
Cell Membrane / metabolism
Diabetes Mellitus, Experimental / metabolism*
Glucagon / blood
Insulin / blood
Liver / metabolism
Pineal Gland / physiology*
Rats, Inbred Strains
Receptor, Insulin / metabolism*
Receptors, Gastrointestinal Hormone / metabolism*
Receptors, Glucagon
Streptozocin / administration & dosage
Reg. No./Substance:
0/Blood Glucose; 0/Receptors, Gastrointestinal Hormone; 0/Receptors, Glucagon; 11061-68-0/Insulin; 18883-66-4/Streptozocin; 9007-92-5/Glucagon; EC, Insulin

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