Document Detail


Effect of pinacidil on rat hearts undergoing hypothermic cardioplegia.
MedLine Citation:
PMID:  7979727     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the effect of pinacidil, a potassium-channel opener, on the hemodynamic, biochemical, and ultrastructural changes in rat hearts undergoing hypothermic cardioplegia. Fifty-four male Wistar rats weighing 250 to 300 g were used. Isolated hearts were prepared for modified Langendorff circulation in the working mode using modified Krebs-Henseleit bicarbonate solution bubbled with a 95% O2 and 5% CO2 gas mixture. Eighty minutes of cardioplegia at 25 degrees C was followed by normothermic reperfusion for 30 minutes. Pinacidil, 5, 10, or 50 mumol/L added to the cardioplegic solution, did not affect heart rate, but is significantly improved the recovery of aortic flow as compared with controls (88.1% +/- 4.3 [5 mumol/L]; 83.2% +/- 8.5% [10 mumol/L]; 90.3% +/- 5.3% [50 mumol/L] compared with 55.6 +/- 4.3% [control]; p < 0.05). Administration of pinacidil during reperfusion did not further enhance the recovery of aortic flow. The dose-response curve of aortic flow to the pinacidil concentrations was flat from 5 to 50 mumol/L. However, preservation of myocardial adenosine triphosphate and calcium concentrations and mitochondrial morphology suggested that the optimal concentration of pinacidil cardioplegia is 10 mumol/L.
Authors:
H Hosoda; M Sunamori; A Suzuki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Annals of thoracic surgery     Volume:  58     ISSN:  0003-4975     ISO Abbreviation:  Ann. Thorac. Surg.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1994-12-28     Completed Date:  1994-12-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  15030100R     Medline TA:  Ann Thorac Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1631-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Thoracic-Cardiovascular Surgery, Tokyo Medical and Dental University, School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Drug
Guanidines / administration & dosage,  pharmacology*
Heart / drug effects*,  physiopathology
Heart Arrest, Induced*
Hypothermia, Induced
Male
Myocardial Reperfusion
Myocardium / cytology
Pinacidil
Rats
Rats, Wistar
Vasodilator Agents / administration & dosage,  pharmacology*
Ventricular Function, Left / drug effects
Chemical
Reg. No./Substance:
0/Guanidines; 0/Vasodilator Agents; 85371-64-8/Pinacidil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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