Document Detail

Effect of phytate on element bioavailability in the second generation of rats.
MedLine Citation:
PMID:  15139384     Owner:  NLM     Status:  MEDLINE    
In this paper the relation between long term consumption of a high dose of sodium phytate and the mineral status of the organism is evaluated in rats. For this purpose, element concentrations (Ca, Mg, Fe, Zn, Mn) were determined in liver, heart, testicle, bone and urine of a second generation of Wistar rats, treated with a phytate free diet (AIN-76A) and with the same diet plus 1% phytate as sodium salt. The most significant differences were observed between bone zinc contents of male and female rats. The zinc content of rats fed a 1% phytate as sodium salt diet resulted clearly lower than that found in no-phytate treated rats. Hence, it is concluded that when up to 1% of phytate as sodium salt is consumed together with an equilibrated purified diet (free of phytate), no decrease in mineral bioavailability is observed in second generation rats, except for an indication of lower zinc availability by lower zinc concentrations in some organs, mainly bone. However, using this purified diet, the zinc concentration in bone resulted around 10 times higher than found in rats fed with a common non purified rat chow.
F Grases; B M Simonet; J Perelló; A Costa-Bauzá; R M Prieto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)     Volume:  17     ISSN:  0946-672X     ISO Abbreviation:  J Trace Elem Med Biol     Publication Date:  2004  
Date Detail:
Created Date:  2004-05-13     Completed Date:  2004-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9508274     Medline TA:  J Trace Elem Med Biol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  229-34     Citation Subset:  IM    
Laboratorio de Investigación en Litiasis Renal, Facultad de Ciencias, Universitat de les Illes Balears, Palma de Mallorca, Spain.
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MeSH Terms
Biological Availability
Bone and Bones / chemistry
Liver / chemistry
Metals / chemistry*,  metabolism
Myocardium / chemistry
Phytic Acid / pharmacokinetics*
Random Allocation
Rats, Wistar
Testis / chemistry
Trace Elements / analysis*
Urine / chemistry
Reg. No./Substance:
0/Metals; 0/Trace Elements; 83-86-3/Phytic Acid

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