Document Detail

Effect of physostigmine and atropine on the single-trial passive avoidance response in rats.
MedLine Citation:
PMID:  7174066     Owner:  NLM     Status:  MEDLINE    
Rats received a single training trial on an inhibitory avoidance (passive avoidance) task and retention trials 24 hr (R-I) and 48 hr (R-II) later, in a special two-chambered apparatus, and the mean step-through latency was determined. The animals were given the drug, either pre-trial, pre-trial plus pre-retention, pre-retention or post-trial. Physostigmine (0.1 mg/kg, ip) and atropine (6.0 mg/kg, ip) had no effect on learning, but they adversely affected retention, particularly at 24 hr. The effect seems to involve central cholinergic mechanisms of retention.
N Jagdev; F S Barar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  26     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:    1982 Jul-Sep
Date Detail:
Created Date:  1983-02-25     Completed Date:  1983-02-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  201-6     Citation Subset:  IM    
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MeSH Terms
Atropine / pharmacology*
Avoidance Learning / drug effects*
Memory, Short-Term / drug effects
Physostigmine / pharmacology*
Reg. No./Substance:
51-55-8/Atropine; 57-47-6/Physostigmine

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