Document Detail

Effect of physiological overload on pregnancy in women with mitral regurgitation.
MedLine Citation:
PMID:  21437435     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: to evaluate the structural and functional heart abnormalities in women with mitral regurgitation during pregnancy.
INTRODUCTION: Women with mitral regurgitation progress well during pregnancy. However, the effects on the heart of the association between pregnancy and mitral regurgitation are not well established.
METHODS: This is a case-control, longitudinal prospective study. Echocardiograms were performed in 18 women with mitral regurgitation at the 12th and 36th week of pregnancy and on the 45th day of the puerperium. Twelve age-matched healthy and pregnant women were included as controls and underwent the same evaluation as the study group.
RESULTS: Compared with controls, women with mitral regurgitation presented increased left cardiac chambers in all evaluations. Increasing left atrium during pregnancy occurred only in the mitral regurgitation group. At the end of the puerperium, women with mitral regurgitation showed persistent enlargement of the left atrium compared with the beginning of pregnancy (5.0 ± 1.1 cm vs 4.6 ± 0.9 cm; p < 0.05). Reduced left ventricular relative wall thickness (0.13 ± 0.02 vs 0.16 ± 0.02; p < 0.05) and an increased peak of afterload (278 ± 55 g/cm² vs 207 ± 28 g/cm²; p < 0.05) was still observed on the 45th day after delivery in the mitral regurgitation group compared with controls.
CONCLUSIONS: Pregnancy causes unfavorable structural alterations in women with mitral regurgitation that are associated with an aggravation of the hemodynamic overload.
Vera T M Borges; Beatriz B Matsubara; Claudia G Magalhães; Jose C Peraçoli; Marilza V C Rudge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinics (São Paulo, Brazil)     Volume:  66     ISSN:  1980-5322     ISO Abbreviation:  Clinics (Sao Paulo)     Publication Date:  2011  
Date Detail:
Created Date:  2011-03-25     Completed Date:  2011-11-02     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  101244734     Medline TA:  Clinics (Sao Paulo)     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  47-50     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil.
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MeSH Terms
Analysis of Variance
Cardiac Volume
Cardiomegaly / etiology
Case-Control Studies
Gestational Age
Heart Defects, Congenital / physiopathology*,  ultrasonography
Hemodynamics / physiology
Mitral Valve Insufficiency / physiopathology*,  ultrasonography
Pregnancy Complications, Cardiovascular / physiopathology*,  ultrasonography
Prospective Studies
Time Factors
Ventricular Function, Left / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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