| Effect of physical training on insulin resistance in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 16799239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The effect of physical training on insulin resistance (IR) in chronic heart failure (CHF) remains unclear. METHODS AND RESULTS: Fourteen patients with CHF performed physical training using a bicycle ergometer; 9 patients (64%) were hyperinsulinemic and insulin resistant (HOMA IR > 1.97). Exercise tolerance increased (5.1 +/- 1.7 to 6.9 +/- 2.7 METs, p < 0.05) and heart rate at rest decreased (82 +/- 15 to 72 +/- 6, p < 0.05) in the IR group after physical training. Physical training also decreased the insulin level (15.1 +/- 5.6 to 9.8 +/- 2.6 microU/ml, p < 0.05) and HOMA IR (3.7 +/- 1.4 to 2.3 +/- 0.6, p < 0.05) in the IR group, but not in the 5 patients (36%) without IR or in 6 control patients. CONCLUSION: Physical training can improve hyperinsulinemia and IR in patients with CHF. |
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Authors:
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Yasuhiro Nishiyama; Motooki Minohara; Masatugu Ohe; Yuji Hirai; Atsushi Katoh; Tetsuya Miyamoto; Gensyo Iwami; Masashi Nakata; Yoshinori Koga |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 70 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-26 Completed Date: 2006-08-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 864-7 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Kurume University Medical Center, Kurume, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chronic Disease Exercise* Female Heart Failure* / blood, complications, physiopathology Heart Rate Humans Insulin / blood Insulin Resistance* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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