| Effect of physical exercise on one-sample antipyrine clearance. | |
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MedLine Citation:
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PMID: 1747507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Moderate physical exercise for a few hours is not expected to reduce the hepatic elimination of drugs exhibiting capacity-limited metabolism (low-clearance drugs such as antipyrine). However, previous studies have shown that antipyrine half-life, measured by the multiple-sampling technique, is increased by exercise. A simplified one-sample procedure for antipyrine clearance determination is increasingly being used as a liver function test. The effects of exercise on this measurement have never been evaluated. We measured antipyrine clearance, using the one-sample, simplified procedure in a group of 50 young Italian army soldiers, while at rest and during a 6 hour march in the mountains (extra energy expenditure: 7.43 kjoule per min). Mean antipyrine clearance was on average 46.6 (SD 10.2) ml/min (range 30.5-65.4) while resting, and 46.2 (10.5) (range 25.5-64.8) while exercising (not different). No specific advice regarding physical exercise is needed whenever liver function is measured in outpatients by the one-sample, simplified antipyrine clearance test. |
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Authors:
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A Fabbri; G Bianchi; M Zoli; E Marchi; G Marchesini |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Italian journal of gastroenterology Volume: 23 ISSN: 0392-0623 ISO Abbreviation: Ital J Gastroenterol Publication Date: 1991 Feb |
Date Detail:
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Created Date: 1992-01-23 Completed Date: 1992-01-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8000544 Medline TA: Ital J Gastroenterol Country: ITALY |
Other Details:
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Languages: eng Pagination: 74-6 Citation Subset: IM |
Affiliation:
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Istituto di Clinica Medica Generale e Terapia Medica, Università di Bologna, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antipyrine / blood, pharmacokinetics* Chromatography, High Pressure Liquid Exercise* Humans Liver / metabolism* Liver Function Tests Male |
| Chemical | |
Reg. No./Substance:
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60-80-0/Antipyrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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