| Effect of physical activity on glutamine metabolism. | |
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MedLine Citation:
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PMID: 19841583 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: Glutamine is largely synthesized in skeletal muscles and provides fuel to rapidly dividing cells of the immune system and precursors to gluconeogenesis in the liver. Physical exercise is known to affect glutamine synthesis and to modulate glutamine uptake. Overtraining is frequently associated with reduced availability of glutamine and decreased immunocompetence. Inactivity affects glutamine metabolism, but this subject was poorly investigated. RECENT FINDINGS: Strenuous physical exercise as well as exhaustive training programs lead to glutamine depletion due to lowered synthesis and enhanced uptake by liver and immune cells. Evidence suggests that postexercise glutamine depletion is associated with immunodepression. Counterwise, moderate training leads to improved glutamine availability due to a positive balance between muscle synthesis and peripheral clearance. Physical inactivity, as investigated by experimental bed rest in healthy volunteers, reduced glutamine synthesis and availability. SUMMARY: After exercise, a reduced glutamine availability may be considered as a marker of overtraining. An increased glutamine availability may contribute to decreased inflammation and health benefits associated with optimal training. Thus, glutamine supplementation may enhance immunocompetence after strenuous exercise. The potential of glutamine supplementation during physical inactivity needs to be explored. |
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Authors:
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Francesco Agostini; Gianni Biolo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current opinion in clinical nutrition and metabolic care Volume: 13 ISSN: 1535-3885 ISO Abbreviation: Curr Opin Clin Nutr Metab Care Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9804399 Medline TA: Curr Opin Clin Nutr Metab Care Country: England |
Other Details:
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Languages: eng Pagination: 58-64 Citation Subset: IM |
Affiliation:
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Department of Medical, Technological and Translational Sciences, Division of Internal Medicine, University of Trieste, Trieste, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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