| Effect of phylloquinone supplementation on glucose homeostasis in humans. | |
| | |
MedLine Citation:
|
PMID: 20881072 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Under-γ-carboxylated osteocalcin (ucOC) increases insulin secretion and decreases glucose concentrations in mice. OBJECTIVE: We determined whether changes in ucOC concentrations in humans were associated with changes in insulin and glucose concentrations. DESIGN: Twenty-one community-dwelling postmenopausal women received 1 mg phylloquinone daily for 12 mo (experimental group), and 21 subjects were treated with a placebo during the same period (control group). Total serum osteocalcin, ucOC, glucose, and insulin concentrations were measured before and 6 and 12 mo after treatment. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated and correlated with ucOC concentrations. RESULTS: Before administration of the placebo or phylloquinone, total osteocalcin, ucOC, glucose, and insulin concentrations and HOMA-IR (1.24 ± 0.15 for the control group compared with 1.93 ± 0.37 for the experimental group) did not differ. After treatment, total osteocalcin concentrations were similar at 6 and 12 mo. At 6 mo, serum ucOC concentrations in the experimental group were 0.96 ± 0.08 ng/mL compared with 2.94 ± 0.27 ng/mL in the control group (P < 0.001). At 12 mo, serum ucOC concentrations were 0.92 ± 0.09 ng/mL and 3.13 ± 0.26 ng/mL (P < 0.001) in experimental and control groups, respectively. Despite a decrease of ≈200% in ucOC concentrations, HOMA-IR was similar in the 2 groups at 6 and 12 mo (at 6 mo, HOMA-IR was 2.24 ± 0.54 and 1.52 ± 0.23 in the experimental and control groups, respectively; at 12 mo, HOMA-IR was 2.13 ± 0.38 and 1.47 ± 0.22 in the experimental and control groups, respectively; P = NS). CONCLUSIONS: In postmenopausal women, phylloquinone administration is not associated with changes in insulin secretion and action despite reductions in ucOC concentrations. Changes in ucOC concentrations do not alter glucose metabolism in women. This trial was registered at clinicaltrials.gov as NCT00062595. |
| | |
Authors:
|
Rajiv Kumar; Neil Binkley; Adrian Vella |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2010-09-29 |
Journal Detail:
|
Title: The American journal of clinical nutrition Volume: 92 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: 2010-12-23 Revised Date: 2011-12-21 |
Medline Journal Info:
|
Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 1528-32 Citation Subset: AIM; IM |
Affiliation:
|
Nephrology Research Unit, Divisions of Nephrology and Hypertension and the Division of Endocrinology and Metabolism, Department of Medicine, Mayo Clinic, Rochester, MN, USA. rkumar@mayo.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Glucose
/
metabolism* Double-Blind Method Female Humans Insulin / blood Insulin Resistance* Middle Aged Osteocalcin / blood* Postmenopause / metabolism Vitamin K 1 / pharmacology* Vitamins / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
|
DK58363/DK/NIDDK NIH HHS; DK76486/DK/NIDDK NIH HHS; DK76829/DK/NIDDK NIH HHS; DK77669/DK/NIDDK NIH HHS; DK82396/DK/NIDDK NIH HHS; R01 DK076829-04/DK/NIDDK NIH HHS; R21 AR058003-02/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Blood Glucose; 0/Insulin; 0/Vitamins; 104982-03-8/Osteocalcin; 84-80-0/Vitamin K 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A simple explanation for the inverse association between height and waist in men.
Next Document: Perioperative arginine-supplemented nutrition in malnourished patients with head and neck cancer imp...