Document Detail

Effect of phthalate esters on the secretion of prostaglandins (F2alpha and E2) and oxytocin in cultured bovine ovarian and endometrial cells.
MedLine Citation:
PMID:  20444570     Owner:  NLM     Status:  MEDLINE    
The influence of phthalate esters di-2-ethylhexyl phthalate (DEHP) and mono-2-ethylhexyl phthalate (MEHP) on uterine prostaglandin (PGF2alpha and PGE2) and ovarian oxytocin secretion was investigated. Endometrial, granulosa, and luteal cells from cows on days 8-12 of the estrous cycle were treated with DEHP or MEHP (0.1, 1, or 10 ng/mL). We found that DEHP and MEHP stimulated (P < 0.05) secretion of PGF2alpha and inhibited (P < 0.001) secretion of PGE2 from endometrial cells. The ratio of PGF2alpha to PGE2 was markedly altered. The endocrine disrupting chemicals also enhanced secretion of oxytocin (P < 0.05) from ovarian cells. Our results indicated that DEHP and its metabolite MEHP could affect the process of the estrous cycle by impairing secretion of prostaglandin from the uterus and oxytocin from the ovary.
Xin Wang; Lixin Shang; Jing Wang; Nan Wu; Shuhe Wang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-05-02
Journal Detail:
Title:  Domestic animal endocrinology     Volume:  39     ISSN:  1879-0054     ISO Abbreviation:  Domest. Anim. Endocrinol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-06     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505191     Medline TA:  Domest Anim Endocrinol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  131-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Department Gynecology and Obstetrics, Beijing Military Region Main Hospital, Dongcheng District, Beijing 100700, China.
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MeSH Terms
Analysis of Variance
Cell Survival / drug effects
Cells, Cultured
Diethylhexyl Phthalate / analogs & derivatives*,  pharmacology*
Dinoprost / secretion*
Dinoprostone / secretion
Endocrine Disruptors / pharmacology*
Endometrium / cytology,  drug effects*,  secretion
Environmental Pollutants / pharmacology
Estrous Cycle / drug effects
Granulosa Cells / cytology,  drug effects,  secretion
Luteal Cells / cytology,  drug effects,  secretion
Ovary / cytology,  drug effects*,  secretion
Oxytocin / drug effects,  secretion
Statistics, Nonparametric
Reg. No./Substance:
0/Endocrine Disruptors; 0/Environmental Pollutants; 117-81-7/Diethylhexyl Phthalate; 363-24-6/Dinoprostone; 4376-20-9/mono-(2-ethylhexyl)phthalate; 50-56-6/Oxytocin; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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