| Effect of phthalate esters on the secretion of prostaglandins (F2alpha and E2) and oxytocin in cultured bovine ovarian and endometrial cells. | |
| | |
MedLine Citation:
|
PMID: 20444570 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The influence of phthalate esters di-2-ethylhexyl phthalate (DEHP) and mono-2-ethylhexyl phthalate (MEHP) on uterine prostaglandin (PGF2alpha and PGE2) and ovarian oxytocin secretion was investigated. Endometrial, granulosa, and luteal cells from cows on days 8-12 of the estrous cycle were treated with DEHP or MEHP (0.1, 1, or 10 ng/mL). We found that DEHP and MEHP stimulated (P < 0.05) secretion of PGF2alpha and inhibited (P < 0.001) secretion of PGE2 from endometrial cells. The ratio of PGF2alpha to PGE2 was markedly altered. The endocrine disrupting chemicals also enhanced secretion of oxytocin (P < 0.05) from ovarian cells. Our results indicated that DEHP and its metabolite MEHP could affect the process of the estrous cycle by impairing secretion of prostaglandin from the uterus and oxytocin from the ovary. |
| | |
Authors:
|
Xin Wang; Lixin Shang; Jing Wang; Nan Wu; Shuhe Wang |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-02 |
Journal Detail:
|
Title: Domestic animal endocrinology Volume: 39 ISSN: 1879-0054 ISO Abbreviation: Domest. Anim. Endocrinol. Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-06 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8505191 Medline TA: Domest Anim Endocrinol Country: United States |
Other Details:
|
Languages: eng Pagination: 131-6 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department Gynecology and Obstetrics, Beijing Military Region Main Hospital, Dongcheng District, Beijing 100700, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Cattle Cell Survival / drug effects Cells, Cultured Diethylhexyl Phthalate / analogs & derivatives*, pharmacology* Dinoprost / secretion* Dinoprostone / secretion Endocrine Disruptors / pharmacology* Endometrium / cytology, drug effects*, secretion Environmental Pollutants / pharmacology Estrous Cycle / drug effects Female Granulosa Cells / cytology, drug effects, secretion Luteal Cells / cytology, drug effects, secretion Ovary / cytology, drug effects*, secretion Oxytocin / drug effects, secretion Statistics, Nonparametric |
| Chemical | |
Reg. No./Substance:
|
0/Endocrine Disruptors; 0/Environmental Pollutants; 117-81-7/Diethylhexyl Phthalate; 363-24-6/Dinoprostone; 4376-20-9/mono-(2-ethylhexyl)phthalate; 50-56-6/Oxytocin; 551-11-1/Dinoprost |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Studying physician-patient communication in the acute care setting: the hospitalist rapport study.
Next Document: Can we predict local recurrence in breast conserving surgery after neoadjuvant chemotherapy?