Document Detail


Effect of phospholipid emulsifiers on physicochemical properties of intravenous fat emulsions and/or drug carrier emulsions.
MedLine Citation:
PMID:  1980297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The physicochemical properties of soy bean oil emulsions stabilized with purified egg lecithins (phosphatides) of various concentrations have been examined. The zeta potential of the emulsion droplets and the mean particle size of oil droplets in 10% (w/w) o/w-type emulsion decreased with increasing emulsifier concentration and then levelled off at more than 1.2% (w/w). In rheological measurements, at the initial stage, the viscosity of 10% (w/w) o/w-type emulsion gradually increased with increasing purified egg lecithin concentration, at the next stage, a plateau was reached at about 1.0-1.4% (w/w), and at the final stage, the viscosity curve showed a dramatic increase. These results indicate that emulsions stabilized by purified egg lecithin at more than 1.2% (w/w) are likely to be sufficiently stable.
Authors:
F Ishii; I Sasaki; H Ogata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  42     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1991-02-28     Completed Date:  1991-02-28     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  513-5     Citation Subset:  IM    
Affiliation:
Meiji College of Pharmacy, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Drug Carriers
Emulsions / chemistry*
Fat Emulsions, Intravenous / chemistry*
Particle Size
Phospholipids / chemistry*
Rheology
Soybean Oil
Viscosity
Chemical
Reg. No./Substance:
0/Drug Carriers; 0/Emulsions; 0/Fat Emulsions, Intravenous; 0/Phospholipids; 8001-22-7/Soybean Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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