Document Detail

Effect of the phosphodiesterase type 5 inhibitor tadalafil on pulmonary hemodynamics in a canine model of pulmonary hypertension.
MedLine Citation:
PMID:  25178687     Owner:  NLM     Status:  Publisher    
Phosphodiesterase type 5 (PDE5) inhibitors are used for treating pulmonary arterial hypertension (PAH) in dogs. The long-acting PDE5 inhibitor tadalafil was recently approved for treatment of PAH in humans. Basic information related to the pharmacological and hemodynamic effects of tadalafil in dogs is scarce. In this study, the hemodynamic effects of tadalafil after intravenous (IV) and oral administration were investigated in a healthy vasoconstrictive PAH Beagle dog model induced by U46619, a thromboxane A2 mimetic. Six healthy Beagle dogs were anesthetized with propofol and maintained with isoflurane. Fluid-filled catheters were placed into the descending aorta to measure systemic arterial pressure and in the pulmonary artery to measure pulmonary arterial pressure (PAP). U46619 was infused via the cephalic vein to induce PAH. IV infusion of U46619 significantly elevated PAP from baseline in a dose-dependent manner. U46619-elevated PAP and pulmonary vascular resistance was significantly attenuated by the simultaneous infusion of tadalafil at 100 and 200 µg/kg/h. Likewise, oral administration of tadalafil at 1.0, 2.0, and 4.0 mg/kg significantly attenuated U46619-elevated PAP in a dose-dependent manner. U46619-elevated systolic and mean PAP decreased significantly 1 h after oral tadalafil administration at 4.0 mg/kg, and this effect was maintained for 6 h. In conclusion, tadalafil had a pharmacological effect in dogs and IV infusion of tadalafil induced pulmonary arterial relaxation, while oral administration of tadalafil decreased PAP. These results suggest that tadalafil may offer a new therapeutic option for treating dogs with PAH.
Yasutomo Hori; Chigusa Kondo; Maho Matsui; Maki Yamagishi; Shozo Okano; Seishiro Chikazawa; Kazutaka Kanai; Fumio Hoshi; Naoyuki Itoh
Related Documents :
9554777 - Case of tumor neovascularization demonstrated by cardiac catheterization.
737597 - Efficacy of systemic heparinization in maintaining patency of the incised and cannulate...
10999367 - Enhanced cardiac thermal dilution analysis for cardiac output, volumes, stroke volumes,...
10982717 - Common pulmonary vein atresia: a diagnostic and therapeutic challenge.
1391187 - Cardiopulmonary function in dogs with serious chronic heartworm disease.
2921577 - Body surface maps of ectopic p waves originating in the left atrium in the dog.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-15
Journal Detail:
Title:  Veterinary journal (London, England : 1997)     Volume:  -     ISSN:  1532-2971     ISO Abbreviation:  Vet. J.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-9-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706281     Medline TA:  Vet J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ltd.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Conjunctival expression of the P2Y2 receptor and the effects of 3% diquafosol ophthalmic solution in...
Next Document:  Prevalence of disorders recorded in cats attending primary-care veterinary practices in England.