Document Detail

Effect of phenytoin on semen.
MedLine Citation:
PMID:  8112236     Owner:  NLM     Status:  MEDLINE    
Male patients receiving antiepileptic drugs (AEDs) have often complained of hyposexuality. Few studies have been done on semen analysis, which is relevant for assessment of potential and possible reproductive outcome in such cases. We evaluated the effect of epilepsy itself and/or phenytoin (PHT) on the male reproductive system. Fifty-five patients with epilepsy (42 with PHT and 13 untreated) and 28 healthy normal controls were studied by semen analysis. Serum samples from 21 of the 55 patients were also analyzed for testosterone, luteinizing hormone (LH), and follicle-stimulating hormone. Results showed lower volume of seminal fluid, spermatozoa concentration, and total sperm count in untreated and PHT-treated patients as compared with controls, although no difference was evident between the patient groups. Morphologically abnormal sperm were more increased in untreated patients than in PHT treated and control subjects. Hormonal analysis showed lower levels of testosterone in 9 patients. LH levels were increased in one third of the patients. Our results suggests an effect of seizures on the male reproductive system, and PHT may have a slight additive (if any) influence.
N Taneja; K Kucheria; S Jain; M C Maheshwari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epilepsia     Volume:  35     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:    1994 Jan-Feb
Date Detail:
Created Date:  1994-03-25     Completed Date:  1994-03-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  136-40     Citation Subset:  IM    
Department of Anatomy and Neurology, AIIMS, Ansari Nagar, New Delhi, India.
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MeSH Terms
Epilepsy / blood,  drug therapy,  physiopathology*
Follicle Stimulating Hormone / blood
Luteinizing Hormone / blood
Phenytoin / adverse effects*,  pharmacology
Semen / drug effects,  physiology*
Sperm Count / drug effects
Spermatogenesis / drug effects
Spermatozoa / drug effects,  physiology
Testis / drug effects,  physiopathology
Testosterone / blood
Reg. No./Substance:
57-41-0/Phenytoin; 58-22-0/Testosterone; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

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