Document Detail

Effect of phenytoin on the immune response in rabbits.
MedLine Citation:
PMID:  873629     Owner:  NLM     Status:  MEDLINE    
Rabbits treated with phenytoin in various ways, were immunized with human serum or with sheep erythrocytes. The antibody response in rabbits injected with the antigen mixed with phenytoin differed distinctly from the response obtained in animals having received the antigen alone or mixed with diluent. The effect of phenytoin on the antibody response depended on the nature of the antigen. The response to some antigens was suppressed, to some potentiated, and to some potentiated in the early phase and then suppressed. The effect comprised both IgM and IgG responses. Skin hypersensitivity tests did not reveal any effect on the cellular immune response. These findings may explain why particularly IgA is affected in patients taking phenytoin by the oral route, and why either reduction or elevation of IgA may occur.
G O Fossan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International archives of allergy and applied immunology     Volume:  54     ISSN:  0020-5915     ISO Abbreviation:  Int. Arch. Allergy Appl. Immunol.     Publication Date:  1977  
Date Detail:
Created Date:  1977-08-25     Completed Date:  1977-08-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404561     Medline TA:  Int Arch Allergy Appl Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  338-46     Citation Subset:  IM    
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MeSH Terms
Antibody Formation / drug effects
Blood Proteins / immunology
Erythrocytes / immunology
Hemagglutination Tests
Immunity / drug effects*
Immunoglobulin G / isolation & purification
Immunoglobulin M / isolation & purification
Phenytoin / pharmacology*
Reg. No./Substance:
0/Antigens; 0/Blood Proteins; 0/Immunoglobulin G; 0/Immunoglobulin M; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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