Document Detail

Effect of phenytoin on the human neuronal activity and depth event-related potential in emotional task.
MedLine Citation:
PMID:  1522029     Owner:  NLM     Status:  MEDLINE    
Neuronal activity and depth ERP were recorded from cortical areas and subcortical nuclei of three patients with diagnostic and/or therapeutic intracerebral electrodes while they were performing emotional task before and after phenytoin administration. Phenytoin acted as a bioelectrical modulator, in some cases increasing and in some cases decreasing the mean background neuronal firing level. In some few cases the more specific task-related effect of phenytoin was found as an inversion of the inhibitory response into the excitatory one in trials evoking negative emotions.
N P Bechtereva; Y G Abdullaev
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of psychophysiology : official journal of the International Organization of Psychophysiology     Volume:  13     ISSN:  0167-8760     ISO Abbreviation:  Int J Psychophysiol     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-10-13     Completed Date:  1992-10-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8406214     Medline TA:  Int J Psychophysiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  25-8     Citation Subset:  IM    
Brain Center, St. Petersburg, Russia.
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MeSH Terms
Brain / drug effects,  physiology
Emotions / physiology*
Evoked Potentials / physiology*
Neurons / drug effects*,  physiology
Phenytoin / pharmacology*
Task Performance and Analysis
Reg. No./Substance:

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