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Effect of phentolamine on myocardial extracellular matrix of cardiac remodeling in rats.
MedLine Citation:
PMID:  25149379     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To study the effects of phentolamine on myocardial extracellular matrix of cardiac remodeling induced by norepinephrine in rats.
METHODS: 24 SD rats were divided into 3 groups randomly: control groups, norepinephrine groups (model groups), norepinephrine +phentolamine groups (treatment groups). Echocardiography was used to detect changes in cardiac structure and function, the level of collagen volume fraction (CVF) and hydroxyproline as well as collagen content were determined in myocardial tissue, matrix metalloproteinases-2 and collagen I in myocardial tissue were localized by immunohistochemitry.
RESULTS: Compared with control groups, left ventricular hypertrophy in the model group rats, the hydroxyproline content and CVF was significantly higher (P<0.01), and matrix metalloproteinase-2 and collagen I protein expression was significantly increased (P<0.01). Phentolamine significantly improved cardiac hypertrophy in treatment group rats, reduced hydroxyproline, CVF, matrix metalloproteinase 2 and collagen I protein expression (P<0.05).
CONCLUSIONS: Phentolamine can effectively reduce the incidence of myocardial hypertrophy and myocardial extracellular matrix remodeling in SD rats, and it can ease myocardial extracellular matrix of cardiac remodeling. It may be associated with reduced expression of matrix metalloproteinase 2 and collagen I in myocardial tissue remodeling.
Authors:
Yi-Gang Yin; Ru-Zhu Wang; Zhong-Bao Ruan; Li Zhu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian Pacific journal of tropical medicine     Volume:  7     ISSN:  1995-7645     ISO Abbreviation:  Asian Pac J Trop Med     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-08-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101533720     Medline TA:  Asian Pac J Trop Med     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  645-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Hainan Medical College. Published by Elsevier B.V. All rights reserved.
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