Document Detail

Effect of phentolamine on the insulin, glucagon, and glucose responses to exercise in adrenal-denervated sheep.
MedLine Citation:
PMID:  3891048     Owner:  NLM     Status:  MEDLINE    
Hyperglycemia and increased hepatic glucose output are characteristic responses to exercise in sheep. They appear to be due in part to alpha-adrenergic stimulation. To delineate the contributions of sympathetic innervation and adrenal catecholamines to the hormonal and metabolic responses to exercise, adrenal-denervated sheep were exercised with and without alpha-blockade (phentolamine treatment). Alpha blockade exaggerated the hyperinsulinemia during exercise (increment of 61 +/- 8 vs. 34 +/- 7 microU/mL for the control). This was associated with a reduction in glucose appearance (increments of 63 +/- 8 vs. 236 +/- 23 mumol/min, respectively). The metabolic clearance rates were not altered by alpha-blockade. It appears that both the adrenal catecholamines and adrenergic innervation to the pancreas contribute to the prevention of a rise in insulin concentrations during exercise in sheep. While this may not be essential for glucose appearance to rise during exercise, it appears necessary for an optimal response.
R P Brockman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  63     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-08-20     Completed Date:  1985-08-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  346-9     Citation Subset:  IM    
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MeSH Terms
Adrenal Glands / innervation*
Blood Glucose / metabolism*
Glucagon / blood*
Insulin / blood*
Phentolamine / pharmacology*
Physical Exertion*
Time Factors
Reg. No./Substance:
0/Blood Glucose; 11061-68-0/Insulin; 50-60-2/Phentolamine; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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