Document Detail

Effect of phenobarbital on cyclophosphamide metabolism in rats.
MedLine Citation:
PMID:  983118     Owner:  NLM     Status:  MEDLINE    
1. The pharmacokinetics of cyclophosphamide and its alkylating metabolites have been studied in rats whose liver microsomal enzymes had been induced by phenobarbital pre-treatment. 2. Serum levels of cyclophosphamide were determined using a new g.l.c. method. The half-life of cyclophosphamide in blood of rats pre-treated with phenobarbital was shorter than in control rats. This change is closely related to higher rates of production of p-nitrobenzylpyridine-positive alkylating metabolites of cyclophosphamide, which in turn is followed by their more rapid disappearance from the circulation. 3. Urinary excretion reflects this situation; lower amounts of cyclophosphamide and higher concentrations of its alkylating metabolites are present in the urine of phenobarbital-treated rats. 4. Perfusion of livers isolated from phenobarbital-pre-treated rats confirmed the results in vivo. With this preparation, too, disappearance of cyclophosphamide was more rapid and formation of its alkylating metabolites was accelerated after phenobarbital treatment.
M G Donelli; A Guaitani; I Bartosek; A Bossi; T Colombo; S Garattini
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  6     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1977-01-03     Completed Date:  1977-01-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  625-31     Citation Subset:  IM    
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MeSH Terms
Alkylating Agents / metabolism
Cyclophosphamide / pharmacology*
Microsomes, Liver / drug effects,  metabolism*
Phenobarbital / pharmacology*
Reg. No./Substance:
0/Alkylating Agents; 50-06-6/Phenobarbital; 50-18-0/Cyclophosphamide

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