Document Detail


Effect of phenobarbital on cyclophosphamide metabolism in rats.
MedLine Citation:
PMID:  983118     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The pharmacokinetics of cyclophosphamide and its alkylating metabolites have been studied in rats whose liver microsomal enzymes had been induced by phenobarbital pre-treatment. 2. Serum levels of cyclophosphamide were determined using a new g.l.c. method. The half-life of cyclophosphamide in blood of rats pre-treated with phenobarbital was shorter than in control rats. This change is closely related to higher rates of production of p-nitrobenzylpyridine-positive alkylating metabolites of cyclophosphamide, which in turn is followed by their more rapid disappearance from the circulation. 3. Urinary excretion reflects this situation; lower amounts of cyclophosphamide and higher concentrations of its alkylating metabolites are present in the urine of phenobarbital-treated rats. 4. Perfusion of livers isolated from phenobarbital-pre-treated rats confirmed the results in vivo. With this preparation, too, disappearance of cyclophosphamide was more rapid and formation of its alkylating metabolites was accelerated after phenobarbital treatment.
Authors:
M G Donelli; A Guaitani; I Bartosek; A Bossi; T Colombo; S Garattini
Related Documents :
6648028 - Intramembranous particle clusters in collecting duct cells of rats. influence of water ...
1920528 - Disposition of [14c]furan in the male f344 rat.
6683228 - The metabolic profile of sodium o-phenylphenate after subchronic oral administration to...
2131828 - Metabolism of methoxychlor by hepatic p-450 monooxygenases in rat and human. 1. charact...
2184138 - Identification of the mononuclear cell infiltrate in the superior cervical ganglion of ...
6856048 - Stimulation of spinal dopaminergic receptors: differential effects on tail reflexes in ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Xenobiotica; the fate of foreign compounds in biological systems     Volume:  6     ISSN:  0049-8254     ISO Abbreviation:  Xenobiotica     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1977-01-03     Completed Date:  1977-01-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1306665     Medline TA:  Xenobiotica     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  625-31     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alkylating Agents / metabolism
Animals
Cyclophosphamide / pharmacology*
Male
Microsomes, Liver / drug effects,  metabolism*
Perfusion
Phenobarbital / pharmacology*
Rats
Chemical
Reg. No./Substance:
0/Alkylating Agents; 50-06-6/Phenobarbital; 50-18-0/Cyclophosphamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Identification of four new metabolic products of metoclopramide using mass spectrometry.
Next Document:  Amylobarbitone hydroxylation kinetics in small samples of rat and human liver.