Document Detail

Effect of phenelzine, a monoamine oxidase inhibitor, on isoproterenol-induced myocardial damage.
MedLine Citation:
PMID:  7423032     Owner:  NLM     Status:  MEDLINE    
The effect of phenelzine on isoproterenol-induced myocardial necrosis was studied in rats. Male albino rats were pretreated with 20 mg/kg body wt of phenelzine, intraperitoneally, on 4 consecutive days. The same animals were given 80 mg/kg of isoproterenol subcutaneously on the third and fourth days of the study. After 48 hr of isoproterenol, ECG was recorded, the animals were killed, and blood, heart, and adrenal glands were removed for biochemical and histopathological studies. Phenelzine returned toward normal the isoproterenol-induced decreased in cardiac glycogen but decreased serum lactic acid only slightly toward normal. The serum enzymes, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT), showed the protective effect of phenelzine. The increase in isoproterenol-induced free fatty acid (FFA) was significantly reduced in the group pretreated with phenelzine. Our studies on adrenal ascorbic acid suggest that the animals pretreated with phenelzine suffered less stress compared to the group treated with isoproterenol alone. Histopathological changes including focal areas of necrosis and characteristic cellular exudation were less marked in the hearts of rats pretreated with phenelzine. S-T segment elevation was more marked in the group treated with isoproterenol only.
K P Singh; K C Joshi; K C Somani; M Tariq
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in myocardiology     Volume:  2     ISSN:  0270-4056     ISO Abbreviation:  Adv Myocardiol     Publication Date:  1980  
Date Detail:
Created Date:  1980-12-16     Completed Date:  1980-12-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8000285     Medline TA:  Adv Myocardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  165-70     Citation Subset:  IM    
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MeSH Terms
Alanine Transaminase / blood
Aspartate Aminotransferases / blood
Heart / drug effects*
Isoproterenol / pharmacology*
Myocardial Infarction / physiopathology
Myocardium / metabolism,  pathology*
Phenelzine / pharmacology*
Reg. No./Substance:
51-71-8/Phenelzine; 7683-59-2/Isoproterenol; EC Aminotransferases; EC Transaminase

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