Document Detail


Effect of phenelzine, a monoamine oxidase inhibitor, on isoproterenol-induced myocardial damage.
MedLine Citation:
PMID:  7423032     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of phenelzine on isoproterenol-induced myocardial necrosis was studied in rats. Male albino rats were pretreated with 20 mg/kg body wt of phenelzine, intraperitoneally, on 4 consecutive days. The same animals were given 80 mg/kg of isoproterenol subcutaneously on the third and fourth days of the study. After 48 hr of isoproterenol, ECG was recorded, the animals were killed, and blood, heart, and adrenal glands were removed for biochemical and histopathological studies. Phenelzine returned toward normal the isoproterenol-induced decreased in cardiac glycogen but decreased serum lactic acid only slightly toward normal. The serum enzymes, serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT), showed the protective effect of phenelzine. The increase in isoproterenol-induced free fatty acid (FFA) was significantly reduced in the group pretreated with phenelzine. Our studies on adrenal ascorbic acid suggest that the animals pretreated with phenelzine suffered less stress compared to the group treated with isoproterenol alone. Histopathological changes including focal areas of necrosis and characteristic cellular exudation were less marked in the hearts of rats pretreated with phenelzine. S-T segment elevation was more marked in the group treated with isoproterenol only.
Authors:
K P Singh; K C Joshi; K C Somani; M Tariq
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Advances in myocardiology     Volume:  2     ISSN:  0270-4056     ISO Abbreviation:  Adv Myocardiol     Publication Date:  1980  
Date Detail:
Created Date:  1980-12-16     Completed Date:  1980-12-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8000285     Medline TA:  Adv Myocardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  165-70     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Alanine Transaminase / blood
Animals
Aspartate Aminotransferases / blood
Heart / drug effects*
Isoproterenol / pharmacology*
Male
Myocardial Infarction / physiopathology
Myocardium / metabolism,  pathology*
Necrosis
Phenelzine / pharmacology*
Rats
Chemical
Reg. No./Substance:
51-71-8/Phenelzine; 7683-59-2/Isoproterenol; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Hypoxic tolerance of rats with isoproterenol-induced myocardial necrosis.
Next Document:  Changes in contractile function and endogenous fuel supply in rat heart upon perfusion with substrat...