| Effect of phencyclidine on dog coronary artery. | |
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MedLine Citation:
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PMID: 9812741 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To study the effect of phencyclidine (Phe) on dog coronary artery. METHODS: Contraction of spiral strips of dog coronary artery in bioassay and coronary artery blood flow (CBF) using electromagnetic flowmeter on anesthetized dogs were observed. RESULTS: Phe 0.1-100 mumol.L-1 induced contraction of strips in a concentration-dependent manner. Dextromethorphan (Dex) 10 mumol.L-1, an antagonist of Phe receptor, antagonized the action of Phe. In vivo, Phe 10 mg.kg-1 increased flow of left circumflex coronary artery of anesthetized dogs from 334 +/- 35 mL.kg-1.min-1 to 510 +/- 58 mL.kg-1.min-1, and both left ventrical pressure (LVP) and blood pressure (BP) rose slowly after medication. Dextromethorphan (Dex) 5 mg.kg-1 also antagonized the effect of Phe. CONCLUSION: The regulation of Phe on coronary artery in vivo differs from that in vitro, which may result in the contradictory effects. |
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Authors:
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G G Shi; D S Wei; B J Liu; S F Xu |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Zhongguo yao li xue bao = Acta pharmacologica Sinica Volume: 17 ISSN: 0253-9756 ISO Abbreviation: Zhongguo Yao Li Xue Bao Publication Date: 1996 May |
Date Detail:
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Created Date: 1999-01-11 Completed Date: 1999-01-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8100330 Medline TA: Zhongguo Yao Li Xue Bao Country: CHINA |
Other Details:
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Languages: eng Pagination: 224-6 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Medical Neurobiology, Shanghai Medical University, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Coronary Circulation / drug effects* Coronary Vessels / drug effects Dextromethorphan / pharmacology Dogs Excitatory Amino Acid Antagonists / pharmacology Female Male Muscle Contraction / drug effects* Muscle, Smooth, Vascular / drug effects* Phencyclidine / pharmacology* Receptors, Phencyclidine / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Excitatory Amino Acid Antagonists; 0/Receptors, Phencyclidine; 125-71-3/Dextromethorphan; 77-10-1/Phencyclidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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