Document Detail

Effect of phasic contractions and tone of the proximal stomach on triggering of transient lower esophageal sphincter relaxation.
MedLine Citation:
PMID:  15259488     Owner:  NLM     Status:  MEDLINE    
We hypothesized that transient lower esophageal sphincter relaxation (TLESR) is triggered by a discrete motor event, i.e., a phasic contraction or a tonic change of the proximal stomach. The combined esophageal manometry-gastric barostat tracings obtained from 11 healthy subjects during 2-hr continuous isobaric gastric distension were reviewed. Volume waves, i.e., phasic contractions, were analyzed in the 1 and 5 min before onset of each TLESR and in corresponding control periods. Intrabag volume, i.e., proximal gastric tone, was also measured in the 5-min periods. The number of volume waves was similar in the 1- and 5-min pre-TLESR and control periods (0 [0-1], median [IQ range], vs 0 [0-1] and 4 [0.8-5] vs 3 [2-4], respectively], and so were their amplitude, duration, and frequency distribution. Five-minute intrabag volume was also similar (529 +/- 77 [mean +/- SE] vs 532 +/- 74 ml). Our observations suggest that TLESR is not triggered by a preceding phasic contraction or by a different tone of the proximal stomach.
M Allocca; R Penagini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  49     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-07-19     Completed Date:  2004-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  710-4     Citation Subset:  AIM; IM    
Dipartimento di Scienze Mediche, University of Milan-IRCCS Ospedale Maggiore, Milan, Italy.
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MeSH Terms
Esophagogastric Junction / physiology*
Gastrointestinal Motility / physiology*
Muscle Contraction / physiology*
Muscle Relaxation / physiology
Muscle, Smooth / physiology
Stomach / physiology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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