Document Detail

Effect of pethidine administered during the first stage of labor on the acid-base status at birth.
MedLine Citation:
PMID:  16406273     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the association between the use of pethidine during the first stage of labor and the presence, type and timing of acidosis in the newborn at birth. STUDY DESIGN: Secondary data analysis of a randomized controlled trial, which included term singleton pregnancies diagnosed with dystocia and requiring active management of labor. Women were randomized to receive either 100 mg of pethidine or placebo. Statistical analyses were performed using chi(2) or Fisher's exact tests for proportions and multiple linear regression for continuous outcomes. RESULTS: Three hundred and eighty-three pregnant women with a valid arterial blood cord sample were included in the final analysis. Lower pH and bicarbonate levels, as well as higher pCO(2) levels were found in the pethidide group. A higher incidence of acidosis was found in the pethidine group (pH<7.12 OR: 8.59 95% C.I. 3.29, 22.46). The highest frequency of acidosis was encountered when pethidine-delivery interval was 5 h. CONCLUSION: Pethidine use during the first stage of labor was associated with an increased risk of acidosis at birth.
Claudio G Sosa; Pierre Buekens; Janet M Hughes; Erica Balaguer; Gonzalo Sotero; Ruben Panizza; Hector Piriz; Justo G Alonso
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2006-01-06
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  129     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-04     Completed Date:  2007-02-20     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  135-9     Citation Subset:  IM    
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Ste. 1820, New Orleans, LA 70112, USA.
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MeSH Terms
Acid-Base Equilibrium / drug effects*
Acidosis / chemically induced*
Analgesics, Opioid / adverse effects*
Fetal Blood / chemistry,  drug effects*
Hospitals, Public
Hydrogen-Ion Concentration
Infant, Newborn
Labor Pain / drug therapy*
Labor Stage, First
Meperidine / adverse effects*
Time Factors
Grant Support
Reg. No./Substance:
0/Analgesics, Opioid; 57-42-1/Meperidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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