| Effect of pethidine administered during the first stage of labor on the acid-base status at birth. | |
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MedLine Citation:
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PMID: 16406273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the association between the use of pethidine during the first stage of labor and the presence, type and timing of acidosis in the newborn at birth. STUDY DESIGN: Secondary data analysis of a randomized controlled trial, which included term singleton pregnancies diagnosed with dystocia and requiring active management of labor. Women were randomized to receive either 100 mg of pethidine or placebo. Statistical analyses were performed using chi(2) or Fisher's exact tests for proportions and multiple linear regression for continuous outcomes. RESULTS: Three hundred and eighty-three pregnant women with a valid arterial blood cord sample were included in the final analysis. Lower pH and bicarbonate levels, as well as higher pCO(2) levels were found in the pethidide group. A higher incidence of acidosis was found in the pethidine group (pH<7.12 OR: 8.59 95% C.I. 3.29, 22.46). The highest frequency of acidosis was encountered when pethidine-delivery interval was 5 h. CONCLUSION: Pethidine use during the first stage of labor was associated with an increased risk of acidosis at birth. |
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Authors:
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Claudio G Sosa; Pierre Buekens; Janet M Hughes; Erica Balaguer; Gonzalo Sotero; Ruben Panizza; Hector Piriz; Justo G Alonso |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2006-01-06 |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 129 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-04 Completed Date: 2007-02-20 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: Ireland |
Other Details:
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Languages: eng Pagination: 135-9 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal Street, Ste. 1820, New Orleans, LA 70112, USA. csosa@tulane.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Equilibrium
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drug effects* Acidosis / chemically induced* Analgesics, Opioid / adverse effects* Female Fetal Blood / chemistry, drug effects* Hospitals, Public Humans Hydrogen-Ion Concentration Infant, Newborn Labor Pain / drug therapy* Labor Stage, First Meperidine / adverse effects* Pregnancy Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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TW05492/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 57-42-1/Meperidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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