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Effect of peroxisome proliferator-activated receptor gamma agonist (pioglitazone) and methotrexate on disease activity in rheumatoid arthritis (experimental and clinical study).
MedLine Citation:
PMID:  21339857     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the combined effect of both pioglitazone and methotrexate on disease activity of rheumatoid arthritis in a biphasic study; experimental and clinical.
METHODS: EXPERIMENTALLY: 50 rats were divided into 5 equal groups; controls, experimental arthritis, methorexate treated (0.1 mg/Kg daily), pioglitazone-treated (10 mg/kg daily), and methotrexate and pioglitazone treated. Clinically: forty-nine diabetic rheumatoid arthritis patients were included. Patients group consisted of 28 patients and they received pioglitazone 30 mg orally beside their usual treatment. Control group consisted of 21 patients and they continued their usual treatment plus placebo. Disease activity was assessed using DAS28 score. Patients were followed up for 3 months.
RESULTS: Pioglitazone produced a significant improvement of serum oxidative stress parameters (P < 0.05), and inflammatory cytokines in the treated arthritic group (P < 0.05). Clinically, the pioglitazone treated group showed significant improvement in DAS28 (P = 0.001) and C-reactive protein (P < 0.0001) compared to placebo group.
CONCLUSION: The concomitant use of the PPAR γ agonist pioglitazone and methotrexate appears to be promising therapeutic strategy for rheumatoid arthritis patients.
Authors:
Dina Shahin; Ehab El Toraby; Hala Abdel-Malek; Vivian Boshra; Ayman Z Elsamanoudy; Dalia Shaheen
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Publication Detail:
Type:  Journal Article     Date:  2011-02-07
Journal Detail:
Title:  Clinical medicine insights. Arthritis and musculoskeletal disorders     Volume:  4     ISSN:  1179-5441     ISO Abbreviation:  Clin Med Insights Arthritis Musculoskelet Disord     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-22     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  101542737     Medline TA:  Clin Med Insights Arthritis Musculoskelet Disord     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  -    
Affiliation:
Department of Internal Medicine, Rheumatology and Immunology, Mansoura Faculty of Medicine, Mansoura, Egypt.
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