Document Detail

Effect of peroxisome proliferator-activated receptor gamma ligand. Rosiglitazone on left ventricular remodeling in rats with myocardial infarction.
MedLine Citation:
PMID:  16891009     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recent studies have demonstrated that PPARgamma ligands have anti-inflammatory effect which is involved in ventricular remodeling. So we hypothesized that PPARgamma ligand may have beneficial effects on post-infarct ventricular remodeling. METHODS: Experimental myocardial infarction (MI) was induced in SD rats by ligation of the left coronary artery. Twenty-four hours after surgery, survival rats were randomly divided into MI group and Rosiglitazone (MI+Ros) group which would take rosiglitazone 3 mg/kg day for 8 weeks. After 8 weeks treatment, left ventricular hemodynamics were measured and organs were weighed. Myocardial collagen analysis was determined in Van Gieson staining by quantitative morphometry. Myocardial angiotensin II and aldosterone were detected by radioimmunoassay. Myocardial AT1 and AT2 mRNA expression were determined by RT-PCR. RESULTS: Only 1 rat in MI group died of anesthesia at the 8th week. Rosiglitazone treatment could improve left ventricular +/-dp/dt(max), collagen volume fraction and perivascular circumferential area; reduce lung/body mass ratio and liver/body mass ratio; inhibit myocardial angiotensin II and aldosterone; and had no significant effects on myocardial AT1 and AT2 mRNA. Plasma insulin and blood glucose were comparable between two groups. CONCLUSIONS: PPARgamma ligand has neutral effect on mortality and beneficial effect on post-infarct ventricular remodeling, partly by suppressing myocardial angiotensin II and aldosterone, irrespective of plasma insulin and blood glucose level.
Deng-feng Geng; Wei Wu; Dong-mei Jin; Jing-feng Wang; Yi-mei Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-08-07
Journal Detail:
Title:  International journal of cardiology     Volume:  113     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-11-06     Completed Date:  2007-01-04     Revised Date:  2007-02-22    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  86-91     Citation Subset:  IM    
Department of Cardiology, The Second Affiliated Hospital, SUN Yat-sen University, West Yanjiang Road, Guangzhou, 510120, China.
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MeSH Terms
Aldosterone Antagonists / pharmacology
Angiotensin II / antagonists & inhibitors
Blood Glucose / metabolism
Body Weight
Collagen / metabolism
Insulin / blood
Liver / pathology
Lung / pathology
Myocardial Infarction / metabolism,  pathology,  physiopathology*
Myocardium / metabolism,  pathology
Organ Size / drug effects
PPAR gamma / metabolism*
Rats, Sprague-Dawley
Thiazolidinediones / pharmacology*
Ventricular Remodeling / drug effects*
Reg. No./Substance:
0/Aldosterone Antagonists; 0/Blood Glucose; 0/Ligands; 0/PPAR gamma; 0/Thiazolidinediones; 11061-68-0/Insulin; 11128-99-7/Angiotensin II; 122320-73-4/rosiglitazone; 9007-34-5/Collagen

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