Document Detail

Effect of perioperative immuno-enhanced enteral nutrition on inflammatory response, nutritional status, and outcomes in head and neck cancer patients undergoing major surgery.
MedLine Citation:
PMID:  21058198     Owner:  NLM     Status:  MEDLINE    
Administration of immuno-enhanced nutritional support may decrease postoperative morbidity, mortality, and infectious complications in cancer patients. The aim of this study was to verify that perioperative enteral diet, enriched with the nutrients arginine, ribonucleic acid (RNA), and ω-3 fatty acids improves outcomes of head and neck cancer patients undergoing major surgery. Forty patients with squamous cell carcinoma of the head and neck were studied. Group 1 received no preoperative nutritional support, whereas Group 2 received an oral formula with nutrients arginine, RNA, and ω-3 fatty acids. After surgery, Group 1 received a standard enteral formula, whereas Group 2 received an enriched enteral formula. Albumin (g/dl), prealbumin, fibrinogen, CRP, Il-6, and TNFa were measured 5 days before and 8 days after surgery. No statistically significant difference was observed for all the evaluated markers between postoperative and preoperative levels for both groups. The rate of complications was significantly reduced in the total number of patients receiving immunonutrition and in the particular subgroup of well-nourished patients receiving an immuno-enhanced diet. Perioperative enteral immuno-enhanced feeding in head and neck cancer patients undergoing major surgery may influence the postoperative outcomes by reducing the frequency rate of infections and wound complications.
Dimitrios Felekis; Anna Eleftheriadou; Georgios Papadakos; Irini Bosinakou; Eliza Ferekidou; Dimitrios Kandiloros; Stylianos Katsaragakis; Konstantinos Charalabopoulos; Leonidas Manolopoulos
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Nutrition and cancer     Volume:  62     ISSN:  1532-7914     ISO Abbreviation:  Nutr Cancer     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-08     Completed Date:  2011-03-08     Revised Date:  2011-03-25    
Medline Journal Info:
Nlm Unique ID:  7905040     Medline TA:  Nutr Cancer     Country:  England    
Other Details:
Languages:  eng     Pagination:  1105-12     Citation Subset:  IM    
Medical School, University of Athens, Hippokration Hospital, Athens, Greece.
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MeSH Terms
Arginine / therapeutic use
Biological Markers / blood
Carcinoma, Squamous Cell / complications,  surgery
Double-Blind Method
Enteral Nutrition*
Fatty Acids, Omega-3 / therapeutic use
Food, Formulated*
Head and Neck Neoplasms / complications,  surgery*
Malnutrition / complications
Middle Aged
Nutritional Status*
Perioperative Care*
Postoperative Complications / blood,  immunology,  prevention & control*
RNA / therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Omega-3; 63231-63-0/RNA; 74-79-3/Arginine

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