| Effect of periodontal treatment on metabolic control, systemic inflammation and cytokines in patients with type 2 diabetes. | |
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MedLine Citation:
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PMID: 19968741 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of this study was to investigate the effect of periodontal therapy on the circulating concentration of high-sensitivity capsule-reactive protein (hs-CRP), fibrinogen (FIB), interleukin (IL)-4, IL-6, IL-8, IL-10 and tumour necrosis factor-alpha (TNF-alpha) and on the metabolic control in type 2 diabetes mellitus (T2DM) patients. MATERIAL AND METHODS: Twenty-three T2DM patients with chronic periodontitis were enrolled in this study. Periodontal clinical parameters, namely visible plaque index, gingival bleeding index, bleeding on probing, probing depth and clinical attachment levels, were evaluated. Blood samples for plasma were collected and assessed for the levels of hs-CRP, FIB, IL-4, IL-6, IL-8, IL-10 and TNF-alpha. The glycated haemoglobin (HbA(1c)) and fasting plasma glucose were also measured. All parameters were evaluated before and 3 months after non-surgical periodontal therapy. RESULTS: All clinical parameters were significantly improved 3 months after the periodontal therapy. A univariate comparison showed a tendency towards a decrease of the measured biomarkers, most pronounced for TNF-alpha and FIB, after therapy. Periodontal treatment also reduced HbA(1c) and hs-CRP levels, albeit not significantly. CONCLUSIONS: The clinically successful non-surgical periodontal therapy tended to reduce systemic inflammation and the concentration of some circulating cytokines. |
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Authors:
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Fernanda O B Correa; Daniela Gon?alves; Carlos M S Figueredo; Alliny S Bastos; Anders Gustafsson; Silvana R P Orrico |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-24 |
Journal Detail:
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Title: Journal of clinical periodontology Volume: 37 ISSN: 1600-051X ISO Abbreviation: J. Clin. Periodontol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-25 Completed Date: 2010-04-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425123 Medline TA: J Clin Periodontol Country: Denmark |
Other Details:
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Languages: eng Pagination: 53-8 Citation Subset: D; IM |
Affiliation:
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Department of Diagnosis and Surgery, School of Dentistry, S?o Paulo State University, Araraquara, SP, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Glucose / analysis C-Reactive Protein / analysis Chronic Periodontitis / blood, therapy* Cytokines / analysis*, blood Dental Plaque Index Dental Scaling Diabetes Mellitus, Type 2 / blood*, prevention & control Female Fibrinogen / analysis Follow-Up Studies Gingival Hemorrhage / therapy Hemoglobin A, Glycosylated / analysis Humans Inflammation Mediators / blood Interleukin-10 / blood Interleukin-4 / blood Interleukin-6 / blood Interleukin-8 / blood Male Middle Aged Periodontal Attachment Loss / therapy Periodontal Index Periodontal Pocket / therapy Root Planing Tumor Necrosis Factor-alpha / analysis |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Cytokines; 0/Hemoglobin A, Glycosylated; 0/Inflammation Mediators; 0/Interleukin-6; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 207137-56-2/Interleukin-4; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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