Document Detail

Effect of perfusate temperature on myocardial protection from ischemia.
MedLine Citation:
PMID:  850437     Owner:  NLM     Status:  MEDLINE    
During reperfusion, functional and metabolic recovery of the isolated working rat heart from one hour of ischemia was best in hearts selectively cooled at the onset of the ischemic interval by perfusion with 5 to 10 ml. of 10 degrees C. or 15 degrees C. Krebs-Henseleit buffer. Hearts similarly perfused at 4 degrees C., 20 degrees C. recovered significantly less well or not at all. Immediately after the hour of ischemia and prior to reperfusion, the absolute levels of glycogen and high-energy phosphates were best in the hearts perfused at 4 degrees C. However, metabolic function was best preserved in those perfused at 10 degrees C. and 15 degrees C., as evidenced by rapid recovery of high-energy phosphates and glycogen to control levels compared to metabolic deterioration in the 4 degrees C. group.
G F Tyers; E H Williams; H C Hughes; G J Todd
Related Documents :
21875887 - Detection of left ventricular apical thrombus with three-dimensional transesophageal ec...
7772907 - The effects of using a leukocyte removal filter during cold blood cardioplegia.
6609757 - Effects of crystalloid and blood cardioplegic solutions on myocardial cooling during my...
10903017 - Esmolol cardioplegia in unstable coronary revascularisation patients. a randomised clin...
7697207 - Electrocardiographic and electrophysiologic properties of cardiac allografts.
7185857 - Concentrations of lead, cadmium, and zinc in human heart muscle and aorta after acute m...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  73     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-05-27     Completed Date:  1977-05-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  766-71     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenosine Triphosphate / metabolism
Cardiac Surgical Procedures*
Coronary Disease / prevention & control*
Glycogen / metabolism
Hypothermia, Induced / methods*
Myocardium / metabolism*
Phosphocreatine / metabolism
Time Factors
Reg. No./Substance:
56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Early operative intervention for complications of acute myocardial infarction.
Next Document:  Monitoring of intraoperative heparinization and blood loss following cardiopulmonary bypass surgery.