Document Detail

Effect of perfluorochemical liquid ventilation on cardiac output and blood pressure variability in neonatal piglets with respiratory insufficiency.
MedLine Citation:
PMID:  10922133     Owner:  NLM     Status:  MEDLINE    
Respiration and mechanical ventilation induce cyclic variation in cardiac output and blood pressure. We examined these phasic hemodynamic influences of mechanical ventilation during gas ventilation and partial and tidal liquid ventilation in 7 anesthetized and paralyzed young piglets (body weight, 3.0-4.9 kg) made respiratory-insufficient by repeated saline lung lavage. Nonlinear regression analysis of cardiovascular parameters vs. time was done to quantify respiratory-induced fluctuations in hemodynamic variables. The amplitude of oscillations was expressed as a percentage of the mean hemodynamic variable during the study period, and was called the relative oscillation amplitude. The relative oscillation amplitude of left ventricular stroke volume, left ventricular output, systemic arterial pressure, and systemic perfusion pressure was significantly larger (at least twofold) during tidal liquid ventilation compared to partial liquid ventilation. No such differences were observed between gas and partial liquid ventilation at comparable gas ventilator settings. We conclude that in this animal model, within-breath modulation of left ventricular output, systemic blood pressure, and perfusion pressure was significantly increased during tidal liquid ventilation as compared to partial liquid ventilation.
P L Degraeuwe; G D Vos; G G Geskens; J M Geilen; C E Blanco
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric pulmonology     Volume:  30     ISSN:  8755-6863     ISO Abbreviation:  Pediatr. Pulmonol.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-09-25     Completed Date:  2000-09-25     Revised Date:  2006-03-28    
Medline Journal Info:
Nlm Unique ID:  8510590     Medline TA:  Pediatr Pulmonol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  114-24     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Wiley-Liss, Inc.
Department of Pediatrics, University Hospital Maastricht, and Research Institute for Growth and Development, Maastricht University, Maastricht, The Netherlands.
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MeSH Terms
Animals, Newborn
Blood Pressure / physiology*
Cardiac Output / physiology*
Disease Models, Animal
Respiration, Artificial*
Respiratory Insufficiency / physiopathology*
Tidal Volume
Ventricular Function, Left
Reg. No./Substance:

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