Document Detail

Effect of peptidoglycan-polysaccharide complex on reproductive efficiency in sheep.
MedLine Citation:
PMID:  15373759     Owner:  NLM     Status:  MEDLINE    
PROBLEM: Spontaneous mastitis or induced infections mimicking mastitis reduce pregnancy rates in ruminants. The effect of immunization with either a mastitis-related pathogen component, peptidoglycan-polysaccharide (PG-PS), or killed Streptococcus pyogenes on pregnancy outcome was investigated. METHOD OF STUDY: Ewe lambs were immunized with PG-PS (n = 50) or killed bacteria (n = 50) or were not immunized (control, n = 100). Titers of PG-PS immunoglobulin G (IgG) were detected by enzyme-linked immunosorbent assay (ELISA). Ewes were bred by rams at synchronized estrus. All immunized ewes and half of the ewes not immunized were challenged with PG-PS on day 5 after breeding. Pregnancy maintenance was evaluated. RESULTS: Although the proportion of ewes pregnant at day 42 after breeding did not differ among treatments, the probability of pregnancy decreased with total dose of PG-PS (P < 0.05). CONCLUSIONS: Immunization of ewe lambs with PG-PS or killed S. pyogenes did not improve pregnancy maintenance. Furthermore, the toxic streptococcal component decreased pregnancy rate in immunized sheep in a dose-dependent manner.
Ida Holásková; Gregory S Lewis; Meenal Elliott; Kenneth P Blemings; Robert A Dailey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  52     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-17     Completed Date:  2005-03-04     Revised Date:  2005-04-08    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  197-203     Citation Subset:  IM    
Division of Animal and Veterinary Sciences, West Virginia University, Morgantown, WV 26506-6108, USA.
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MeSH Terms
Peptidoglycan / immunology*
Polysaccharides / immunology*
Pregnancy Outcome
Pregnancy, Animal / immunology*,  physiology
Reproduction / immunology*,  physiology*
Sheep / physiology*
Reg. No./Substance:
0/Peptidoglycan; 0/Polysaccharides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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