Document Detail

Effect of pattern of breathing on subfractions of surfactant in tissue and alveolar compartments of the adult rat lung.
MedLine Citation:
PMID:  2390266     Owner:  NLM     Status:  MEDLINE    
We have used tow previously characterized models of hyperpnea in vivo and different modes of ventilation in the isolated perfused rat lung to investigate changes in the phospholipid content of tubular myelin-rich (PLalv-1) and -poor (PLalv-2) fractions isolated from lavaged material and of two lamellar body subfractions. A vesicular lamellar body subfraction (lbB) was preferentially released during 30-min swimming. However, during the subsequent 3-h recovery period there was a preferential supplementation of the classic-appearing lamellar body fraction (lbA). Hyperpnea induced by exposure to 5% CO2/13% O2/82% N2 led to an increase in lbA after 12 h and in lbB after 48 h. Whereas PLalv-2 was elevated above control values after 8 h, PLalv-1 remained unchanged until 24 h. In the perfused lung isolated from rats infused with [methyl-3H]choline chloride 3 h previously, salbutamol, a deep breath, and increased tidal volume (VT) all increased total alveolar phospholipids; however, the pattern of change was very different. Salbutamol markedly elevated PLalv-1 and increased the specific activity of both alveolar fractions. In contrast, a single deep breath increased PLalv-2 while slightly increasing the specific activity of PLalv-1. Finally, an increased VT decreased PLalv-1 while inducing a large increase in PLalv-2; it increased specific activity in both alveolar fractions. Both salbutamol and an increased VT decreased phospholipids in lbA. We conclude that lbA and lbB vary in their response to different stimuli. In vivo, PLalv-1, the tubular myelin-rich fraction, remains very constant, a fact consistent with its being the controlled variable in surfactant homeostasis.(ABSTRACT TRUNCATED AT 250 WORDS)
T E Nicholas; J H Power; H A Barr
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory cell and molecular biology     Volume:  3     ISSN:  1044-1549     ISO Abbreviation:  Am. J. Respir. Cell Mol. Biol.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-10-03     Completed Date:  1990-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8917225     Medline TA:  Am J Respir Cell Mol Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  251-8     Citation Subset:  IM    
Department of Human Physiology, School of Medicine, Flinders University of South Australia, Adelaide.
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MeSH Terms
Albuterol / pharmacology
Biological Products*
Models, Biological
Myelin Sheath
Phospholipids / metabolism*
Pulmonary Alveoli / drug effects,  metabolism*
Pulmonary Surfactants / analysis*,  metabolism*
Reproducibility of Results
Reg. No./Substance:
0/Biological Products; 0/Phospholipids; 0/Proteins; 0/Pulmonary Surfactants; 0/tubular myelin; 18559-94-9/Albuterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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