| Effect of a patent foramen ovale on pulmonary gas exchange efficiency at rest and during exercise. | |
| | |
MedLine Citation:
|
PMID: 21372097 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The prevalence of a patent foramen ovale (PFO) is ~30%, and this source of right-to-left shunt could result in greater pulmonary gas exchange impairment at rest and during exercise. The aim of this work was to determine if individuals with an asymptomatic PFO (PFO+) have greater pulmonary gas exchange inefficiency at rest and during exercise than subjects without a PFO (PFO-). Separated by 1 h of rest, 8 PFO+ and 8 PFO- subjects performed two incremental cycle ergometer exercise tests to voluntary exhaustion while breathing either room air or hypoxic gas [fraction of inspired O(2) (FI(O(2))) = 0.12]. Using echocardiography, we detected small, intermittent boluses of saline contrast bubbles entering directly into the left atrium within 3 heart beats at rest and during both exercise conditions in PFO+. These findings suggest a qualitatively small intracardiac shunt at rest and during exercise in PFO+. The alveolar-to-arterial oxygen difference (AaDo(2)) was significantly (P < 0.05) different between PFO+ and PFO- in normoxia (5.9 ± 5.1 vs. 0.5 ± 3.5 mmHg) and hypoxia (10.1 ± 5.9 vs. 4.1 ± 3.1 mmHg) at rest, but not during exercise. However, arterial oxygen saturation was significantly different between PFO+ and PFO- at peak exercise in normoxia (94.3 ± 0.9 vs. 95.8 ± 1.0%) as a result of a significant difference in esophageal temperature (38.4 ± 0.3 vs. 38.0 ± 0.3°C). An asymptomatic PFO contributes to pulmonary gas exchange inefficiency at rest but not during exercise in healthy humans and therefore does not explain intersubject variability in the AaDO(2) at maximal exercise. |
| | |
Authors:
|
Andrew T Lovering; Michael K Stickland; Markus Amann; Matthew J O'Brien; John S Hokanson; Marlowe W Eldridge |
Related Documents
:
|
22592277 - Oxygen cost of breathing and breathlessness during exercise in nonobese women and men. 21326387 - The extent of aerobic system activation during continuous and interval exercise protoco... 21352507 - Il-6 modifies mrna expression in mouse. 12070627 - Reproducibility of the blood lactate threshold, 4 mmol.l(-1) marker, heart rate and rat... 3876407 - Entry of methotrexate into streptococcus pneumoniae: a study on a wild-type strain and ... 17149987 - Short-term plyometric training improves running economy in highly trained middle and lo... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-03-03 |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 110 ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-05-12 Completed Date: 2011-09-30 Revised Date: 2012-05-01 |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1354-61 Citation Subset: IM |
Affiliation:
|
University of Oregon, Department of Human Physiology, Eugene, Oregon, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Foramen Ovale, Patent
/
physiopathology* Humans Middle Aged Physical Endurance* Physical Exertion* Pulmonary Gas Exchange* Rest* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
|
K99 HL103786-01/HL/NHLBI NIH HHS; K99 HL103786-02/HL/NHLBI NIH HHS; R01 HL086897-04/HL/NHLBI NIH HHS; //Canadian Institutes of Health Research |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Acute effects of hydrogen peroxide on skeletal muscle microvascular oxygenation from rest to contrac...
Next Document: Cerebral autoregulation dynamics in endurance-trained individuals.