Document Detail

Effect of passive smoking on thyroid function in infants.
MedLine Citation:
PMID:  9578503     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the effect of passive smoking on thyroid function in infants. DESIGN AND METHODS: Cord serum tri-iodiothyronine (T3), free T3 (fT3), thyroxine (T4), free T4 (fT4), TSH, thyroxine binding globulin (TBG), thyroglobulin (TG) and cord plasma thiocyanate were measured at birth, and serum TG and thiocyanate after 1 year of life, in 18 infants born from parents who did not smoke (group A), in 18 infants with a father who smoked (group B) and in 18 infants with parents both being smokers (group C). RESULTS: No significant differences were observed in cord serum concentrations of T3, fT3, T4, fT4, TSH and TBG among the three groups. Median (range) TG concentrations (ng/ml) were 30.2 (5.0-102.0), 56.3 (20.5-208.0) and 76.0 (26.0-199.0) at birth (P=0.009 for groups A and B compared; P=0.0002 for groups A and C compared), and 14.9 (5.4-32.0), 19.5 (10.0-57.5) and 20.0 (14.0-40.7) at 1 year (P=0.017 for groups A and C compared), in the three groups respectively, and thiocyanate concentrations (mmol/l) were 3.3 (0.0-51.4), 12.9 (0.0-122.2) and 27.8 (3.3-184.5) at birth (P=0.015 for groups A and C compared), and 3.1 (0.0-32.7), 6.0 (0.0-47.3) and 20.3 (0.0-230.8) at 1 year (P=0.01 for groups A and C compared) in the three groups respectively. CONCLUSIONS: TG and thiocyanate concentrations at birth and at 1 year of age in infants of smoking parents are greater than in infants with non-smoking parents. These results indicate that the change in thyroid function as evaluated by serum TG concentrations observed at birth can persist at least for 1 year if the exposure to passive smoking from both parents is continued. Increased TG concentrations may be due to a direct effect of thiocyanate on the thyroid gland.
A Gasparoni; M Autelli; M F Ravagni-Probizer; A Bartoli; M Regazzi-Bonora; G Chirico; G Rondini
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  138     ISSN:  0804-4643     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-05-27     Completed Date:  1998-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  379-82     Citation Subset:  IM    
Research Laboratories (Pediatric Oncohaematology and Neonatal Immunology, Policlinico San Matteo, IRCCS, Pavia, Italy.
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MeSH Terms
Analysis of Variance
Fetal Blood / metabolism*
Infant, Newborn
Risk Factors
Thyroid Gland / physiopathology*
Thyroid Hormones / blood*
Tobacco Smoke Pollution / adverse effects*
Reg. No./Substance:
0/Thyroid Hormones; 0/Tobacco Smoke Pollution
Comment In:
Eur J Endocrinol. 1998 Apr;138(4):368-9   [PMID:  9578499 ]

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