Document Detail

Effect of partially purified human somatomedin on human fetal and postnatal cartilage in vitro.
MedLine Citation:
PMID:  6884255     Owner:  NLM     Status:  MEDLINE    
Partly purified somatomedin prepared from adult human plasma stimulated [3H]thymidine and [35S]sulphate uptake into human cartilage. At a final concentration of 0.1 U/ml somatomedin the uptake of [3H]thymidine into fetal cartilage at 18 weeks of gestation was 162 +/- 23% compared with controls. Somatomedin also increased the incorporation of [35S]sulphate into fetal cartilage to 137 +/- 22% at 18 weeks compared to controls. The same concentration of somatomedin (0.1 U/ml) also increased the incorporation of [3H]thymidine into postnatal articular cartilage to 239 +/- 69% and [35S]sulphate to 133 +/- 28% compared to controls. Human somatomedin prepared from adult plasma thus has a mitogenic effect on both fetal and postnatal cartilage. The smaller effect on fetal cartilage may reflect different forms of somatomedin and/or differences in receptors for somatomedins on adult and fetal chondrocytes.
I K Ashton; E M Spencer
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Early human development     Volume:  8     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-10-28     Completed Date:  1983-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  135-40     Citation Subset:  IM    
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MeSH Terms
Cartilage / drug effects*,  embryology,  metabolism
Cartilage, Articular / drug effects,  metabolism
Fetus / drug effects*,  metabolism
Somatomedins / pharmacology*
Sulfates / metabolism
Thymidine / metabolism
Tritium / diagnostic use
Reg. No./Substance:
0/Somatomedins; 0/Sulfates; 10028-17-8/Tritium; 50-89-5/Thymidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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