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Effect of partial liquid ventilation on oleic acid-induced inflammatory responses in piglets.
MedLine Citation:
PMID:  20819547     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Pediatric patients are susceptible to lung injury. Acute lung injury (ALI) in children often results in a high mortality. Partial liquid ventilation (PLV) has been shown to markedly improve oxygenation and reduce histologic evidence of injury in a number of lung injury models. This study aimed to examine the hypothesis that PLV would attenuate the production of local and systemic cytokines in an immature piglet model of ALI induced by oleic acid (OA).
METHODS: Twelve Chinese immature piglets were induced to develop ALI by oleic acid. The animals were randomly assigned to two groups (n = 6): (1) conventional mechanical ventilation (MV) group and (2) PLV with FC-77 (10 ml/kg) group.
RESULTS: Compared with MV group, PLV group got better cardiopulmonary variables (P < 0.05). These variables included heart rate, mean blood pressure, blood pH, partial pressure of arterial oxygen (PaO2), PaO2/FiO2 and partial pressure of arterial carbon dioxide (PaCO2). Partial liquid ventilation reduced IL-1beta, IL-6, IL-10 and TNF-alpha both in plasma and tissue concentrations compared with MV group (P < 0.05).
CONCLUSIONS: Partial liquid ventilation provides protective effects against inflammatory responses in the lungs of oleic acid-induced immature piglets.
Authors:
Yao-bin Zhu; Qiang Wang; Ying-long Liu; Xiao-feng Li; Jian-an Li; Xiao-dong Lü; Feng Ling; Ai-jun Liu; Xiang-ming Fan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chinese medical journal     Volume:  123     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-09-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  2088-93     Citation Subset:  IM    
Affiliation:
Department of Pediatric Cardiac Surgery Center, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
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