Document Detail

Effect of parenteral serum plant sterols on liver enzymes and cholesterol metabolism in a patient with short bowel syndrome.
MedLine Citation:
PMID:  18682596     Owner:  NLM     Status:  MEDLINE    
Hepatobiliary complications are common during parenteral nutrition. Lipid moiety in commercially available solutions contains plant sterols. It is not known whether plant sterols in parenteral nutrition interfere with hepatic function in adults. We detected how different amounts of plant sterols in parenteral nutrition solution affected serum plant sterol concentrations and liver enzymes during a 1.5-year follow-up in a patient with short bowel syndrome. Serum lipid, plant sterol, and liver enzyme levels were measured regularly during the transition from Intralipid (100% soy-based intravenous fat emulsion) to ClinOleic (an olive oil-based intravenous fat emulsion with 80% olive oil, 20% soy oil and lower plant sterols); the lipid supply was also gradually increased from 20 to 35 g/d. Plant sterols in parenteral nutrition solution and serum were measured with gas-liquid chromatography. During infusion of soy-based intravenous fat emulsion (30 g/d, total plant sterols 87 mg/d), the concentrations of sitosterol, campesterol, and stigmasterol were 4361, 1387, and 378 microg/dL, respectively, and serum liver enzyme values were >or= 2.5 times above upper limit of normal. After changing to olive oil-based intravenous fat emulsion (20-35 g/d, plant sterols 37-65 mg/d), concentrations decreased to 2148 to 2251 microg/dL for sitosterol, 569-297 microg/dL for campesterol, and 95-55 microg/dL for stigmasterol. Concomitantly, liver enzyme values decreased to 1.4 to 1.8 times above upper limit of normal at the end of follow-up. The nutrition status of the patient improved. The amount of plant sterols in lipid emulsion affects serum liver enzyme levels more than the amount of lipid.
Maarit Hallikainen; Laura Huikko; Kirsi Kontra; Markku Nissinen; Vieno Piironen; Tatu Miettinen; Helena Gylling
Related Documents :
15092736 - Detection of sulphite in plants.
22489806 - Stress-reducing effects of real and artificial nature in a hospital waiting room.
22538226 - Surveying of pollen-mediated crop-to-crop gene flow from a wheat field trial as a biosa...
19933266 - Knock-down of osdcl2 in rice negatively affects maintenance of the endogenous dsrna vir...
16679166 - Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm.
20796136 - Genetic variation in herbivore resistance and tolerance: the role of plant life-history...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition     Volume:  23     ISSN:  0884-5336     ISO Abbreviation:  Nutr Clin Pract     Publication Date:    2008 Aug-Sep
Date Detail:
Created Date:  2008-08-06     Completed Date:  2009-01-06     Revised Date:  2010-04-29    
Medline Journal Info:
Nlm Unique ID:  8606733     Medline TA:  Nutr Clin Pract     Country:  United States    
Other Details:
Languages:  eng     Pagination:  429-35     Citation Subset:  IM; N    
Department of Clinical Nutrition, University of Kuopia, P.O. Box 1627 Kuopia, Finland FIN-70211.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cholesterol / blood,  metabolism*
Chromatography, Gas
Dose-Response Relationship, Drug
Fat Emulsions, Intravenous / administration & dosage,  therapeutic use
Follow-Up Studies
Infusions, Intravenous
Lipids / administration & dosage,  blood
Liver / drug effects,  enzymology,  metabolism*
Nutrition Assessment
Nutritional Status / drug effects*
Parenteral Nutrition / methods*
Phytosterols / administration & dosage,  blood*
Plant Oils / administration & dosage
Short Bowel Syndrome / blood,  diet therapy*
Reg. No./Substance:
0/Fat Emulsions, Intravenous; 0/Lipids; 0/Phytosterols; 0/Plant Oils; 57-88-5/Cholesterol; 8001-25-0/olive oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Validation of a new method developed to measure the height of adult patients in bed.
Next Document:  10-year review of pediatric intestinal failure: clinical factors associated with outcome.