| Effect of parenteral and early intrajejunal nutrition on pancreatic digestive enzyme synthesis, storage and discharge in dog models of acute pancreatitis. | |
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MedLine Citation:
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PMID: 17373751 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To study the effect of early intrajejunal nutrition on enzyme-protein synthesis and secretion during acute pancreatitis. METHODS: Fifteen dogs were randomly divided into parenteral nutrition (n = 7) and early intrajejunal nutrition groups (n = 8). An acute pancreatitis model was induced by injecting 5% sodium taurocholate and trypsin into the pancreas via the pancreatic duct. Intrajejunal nutrition was delivered with a catheter via a jejunostomy tube after the model was established for 24 h. On d 1 and 7 and at the beginning of nutritional support, radioactive tracing and electron microscopes were used to evaluate the enzyme-protein synthesis in acinar cells, the subcellular fractionation and the change in zymogen granules after 1.85 x 10(6) Bq L-(3)H phenylalanine was infused at 30, 60, 120, and 180 min. RESULTS: The 3H radioactivity in pancreatic acinar cells reached its peak level at 60 min, and the contents in the early intrajejunal nutrition group were higher than those in the parenteral nutrition group, which were then decreased. The mean number and area of zymogen granules did not show any significant statistical difference in both groups on d 1 or on d 7 (P > 0.05). CONCLUSION: Early intrajejunal nutrition might be effective in dogs with acute pancreatitis. |
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Authors:
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Huan-Long Qin; Zhen-Dong Su; Lei-Guang Hu; Zai-Xian Ding; Qing-Tian Lin |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 13 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-03-21 Completed Date: 2007-06-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 1123-8 Citation Subset: IM |
Affiliation:
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Institute of Parenteral Nutrition and Enteral Nutrition, Department of Surgery, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Yishan Rd. 600, Shanghai 200233, China. hlqin@sjtu.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Amylases / metabolism* Animals Cathepsin B / metabolism* Detergents Disease Models, Animal Dogs Electron Transport Complex IV / metabolism* Enteral Nutrition / methods* Lysosomes / enzymology Pancreas / enzymology, pathology, ultrastructure Pancreatitis / chemically induced, enzymology*, pathology Parenteral Nutrition / methods* Secretory Vesicles / enzymology Taurocholic Acid |
| Chemical | |
Reg. No./Substance:
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0/Detergents; 81-24-3/Taurocholic Acid; EC 1.9.3.1/Electron Transport Complex IV; EC 3.2.1.-/Amylases; EC 3.4.22.1/Cathepsin B |
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