Document Detail

Effect of parenteral amino acids on human pancreatic exocrine secretion.
MedLine Citation:
PMID:  2581745     Owner:  NLM     Status:  MEDLINE    
Parenteral administration of amino acids has been utilized for the nutritional support of patients with a variety of gastrointestinal disorders including protracted pancreatitis and pancreatic fistulae. However, the effect of parenteral amino acid administration alone on human pancreatic secretion has not been studied. We have studied the short-term effect of parenteral administration of amino acids on pancreatic exocrine secretion in seven healthy men. A double-lumen tube was placed in the duodenum and polyethylene glycol was perfused into the proximal duodenum at the rate of 10 ml/min. A second double-lumen tube was placed in the stomach and bromsulfthalein was perfused into the cardia. Samples of duodenal contents were aspirated and gastric contents recovered during one hour of intravenous saline infusion followed by two hours of an amino acid mixture infusion. Hourly outputs of protein and pancreatic enzymes were determined, correcting for duodenogastric reflux based on concentrations of both markers in the samples. Despite an average increase of 72% in the plasma concentration of the infused amino acids, the outputs of protein, trypsin and amylase did not change significantly during amino acid infusion; the output of lipase decreased significantly during amino acid infusion. Two subjects were given intravenous secretin and cholecystokinin following amino acids; this resulted in increased outputs of protein, trypsin, and amylase in both. We conclude that the parenteral administration of amino acids to healthy young men does not stimulate pancreatic enzyme secretion as measured by the method using duodenal marker perfusion at the rate of 10 ml/min.
E P Variyam; R K Fuller; F M Brown; L G Quallich
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  30     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-07-12     Completed Date:  1985-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  541-6     Citation Subset:  AIM; IM    
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MeSH Terms
Amino Acids / administration & dosage,  pharmacology*
Amylases / secretion
Gastric Acid / secretion
Lipase / secretion
Pancreas / drug effects,  secretion*
Parenteral Nutrition
Proteins / secretion
Trypsin / secretion
Reg. No./Substance:
0/Amino Acids; 0/Proteins; EC; EC 3.2.1.-/Amylases; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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