Document Detail

Effect of parental smoking on cotinine levels in newborns.
MedLine Citation:
PMID:  17580319     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Smoking is a major risk factor for cot death. Many infants smoke passively as a result of parental smoking. This paper reports on infants exposed to a smoking environment and how they accumulate metabolites of cigarette smoke, such as cotinine, which may be physiologically harmful.
AIM: To assess cotinine levels in infants of smoking parents.
METHOD: Cotinine excretion in urine was assessed in 104 infants, of whom 71 had smoking parents and 33 had non-smoking parents. All cotinine levels were measured at approximately 12 weeks of age. The subjects were selected from a database of infants in developmental physiological studies which assessed the impact of various factors on early postnatal development.
RESULTS: On average babies with at least one parent who was a current cigarette smoker excreted 5.58 (95% CI 3.4 to 9.5) times as much cotinine in the urine as did the babies of non-smoking parents. Maternal smoking was the largest contributing factor. Co-sleeping (p = 0.037) and the minimum room temperature (p = 0.028) were significant contributory factors.
CONCLUSION: Infants from smoking households accumulate cotinine, a metabolite of nicotine, which may have a detrimental effect on the cardiorespiratory system.
D V Joseph; J A Jackson; J Westaway; N A Taub; S A Petersen; M P Wailoo
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Publication Detail:
Type:  Journal Article     Date:  2007-06-19
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  92     ISSN:  1468-2052     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-22     Completed Date:  2007-12-11     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F484-8     Citation Subset:  AIM; IM    
University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, UK.
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MeSH Terms
Case-Control Studies
Cotinine / urine*
Infant, Newborn
Linear Models
Multivariate Analysis
Risk Factors
Sudden Infant Death / etiology,  prevention & control
Tobacco Smoke Pollution / adverse effects*
Reg. No./Substance:
0/Tobacco Smoke Pollution; 486-56-6/Cotinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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