Document Detail

Effect of parathyroid hormone on renal calcium and magnesium reabsorption in magnesium deficient rats.
MedLine Citation:
PMID:  7191964     Owner:  NLM     Status:  MEDLINE    
Tubular magnesium reabsorption was investigated by recollection micropuncture and in vivo microperfusion techniques in acutely thyroparathyroidectomized rats made magnesium deficient by dietary deprivation. Henle's loop which normally reclaims the major portion of filtered magnesium was examined by elevation of intraluminal magnesium concentration. The transport capacity in these conditions was significantly lower in magnesium deficient rats (41%) compared to normal animals (71%) at comparable magnesium delivery rates. Acute infusion of MgCl2 further depressed loop magnesium reabsorption independent of intraluminal magnesium delivery. Parathyroid hormone did not alter magnesium transport capacity in magnesium deficient rats but resulted in enhanced transport in acutely hypermagnesemic deficient rats. Calcium reabsorption followed a similar qualitative pattern as magnesium with respect to loop function and urinary excretion. These results are consistent with a depressed transport capacity for magnesium in the loop of Henle of magnesium deficient rats which is independent of intraluminal magnesium delivery and circulating parathyroid hormone level.
G A Quamme; S L Carney; N L Wong; J H Dirks
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  386     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1980 Jul 
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  59-65     Citation Subset:  IM    
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MeSH Terms
Biological Transport / drug effects
Calcium / metabolism*
Glomerular Filtration Rate
Kidney / physiopathology
Kidney Tubules / metabolism*
Loop of Henle / metabolism*
Magnesium / metabolism*
Magnesium Deficiency / metabolism*,  physiopathology
Parathyroid Hormone / pharmacology*
Reg. No./Substance:
0/Parathyroid Hormone; 7439-95-4/Magnesium; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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