Document Detail


Effect of paracetamol on uric acid determination.
MedLine Citation:
PMID:  15637909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of paracetamol on uric acid determination using a phosphotungstate reduction method has been investigated. The results show that apparently raised values of serum uric acid may be reported in patients receiving therapeutic levels of this drug. Levels of serum uric acid were determined over a five-hour period in three patients who had received therapeutic doses of paracetamol. The assays of serum uric acid were performed by a method based on phosphotungstate reduction and by one employing uricase. The results illustrate the problems of using the former method for clinical purposes.
Authors:
P Wilding; D A Heath
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  12     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  1975 Jul 
Date Detail:
Created Date:  2005-01-10     Completed Date:  2005-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  142-4     Citation Subset:  IM    
Affiliation:
Department of Clinical Chemistry, Queen Elizabeth Medical Centre, Birmingham.
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MeSH Terms
Descriptor/Qualifier:
Acetaminophen / blood,  poisoning*,  therapeutic use*
Adult
Anticonvulsants / adverse effects
Autoanalysis / instrumentation,  methods*
Bromides / adverse effects
Diazepam / adverse effects
Dose-Response Relationship, Drug
Drug Interactions
False Positive Reactions
Female
Humans
Overdose
Oxidation-Reduction
Phenobarbital / adverse effects
Phenytoin / adverse effects
Phosphotungstic Acid / diagnostic use
Severity of Illness Index
Substance-Related Disorders
Time Factors
Urate Oxidase / diagnostic use
Uric Acid / blood*
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Bromides; 103-90-2/Acetaminophen; 12067-99-1/Phosphotungstic Acid; 439-14-5/Diazepam; 50-06-6/Phenobarbital; 57-41-0/Phenytoin; 69-93-2/Uric Acid; EC 1.7.3.3/Urate Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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