Document Detail

Effect of paracetamol, mephenoxalone and their combination on pain following bone surgery.
MedLine Citation:
PMID:  786667     Owner:  NLM     Status:  MEDLINE    
Sixty patients suffering moderate postoperative pain after bone surgery were divided randomly into 3 treatment groups on the day following operation. Under double blind conditions they received either 400 mg mephenoxalone, a weak sedative, or 900 mg paracetamol, or the same doses of these drugs simultaneously, three times daily for three days. Pain scores determined by a surgeon 1, 2, 3, and 6 hours after administration of the first dose of the drug indicated that paracetamol and paracetamol + mephenoxalone had similar analgesic effects and were more effective than mephenoxalone alone. However, during repeated administration over 3 days, the mean effect of the drug combination was slightly better than that of paracetamol or mephenoxalone alone. The drug combination did not induce more sedation or gastrointestinal side effects than either drug alone.
J Eskenazi; T Nikiforidis; J J Livio; J L Schelling
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  09     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-12-03     Completed Date:  1976-12-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  411-5     Citation Subset:  IM    
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MeSH Terms
Acetaminophen / administration & dosage,  adverse effects,  therapeutic use*
Bone and Bones / surgery*
Clinical Trials as Topic
Drug Administration Schedule
Drug Synergism
Drug Therapy, Combination
Oxazoles / administration & dosage,  adverse effects,  therapeutic use*
Pain, Postoperative / drug therapy*
Reg. No./Substance:
0/Oxazoles; 103-90-2/Acetaminophen

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