| Effect of pH on mutagenesis by thiols in Salmonella typhimurium TA102. | |
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MedLine Citation:
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PMID: 2671715 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mutagenicity of thiol (SH)-containing compounds was tested in Salmonella typhimurium TA102 in the liquid preincubation method. Cysteinyl-glycine (CG), cysteine ethyl ester (CEE), L- and D-penicillamine (PA), cysteine (Cys) and glutathione (GSH) were mutagenic to strain TA102 without metabolic activation. On a molar basis, CG was the most potent mutagen. The mutagenicity of the remaining compounds decreased in the order specified above. The mutagenic response of each thiol-containing compound was a function of the pKa of the thiol group and the pH of the preincubation mixture. This indicates that a thiolate anion, rather than a free thiol, is required for mutagenesis. |
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Authors:
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A A Stark; A Arad; S Siskindovich; D A Pagano; E Zeiger |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Mutation research Volume: 224 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1989 Sep |
Date Detail:
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Created Date: 1989-10-06 Completed Date: 1989-10-06 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 89-94 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Tel-Aviv University, Ramat-Aviv, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chemical Phenomena Chemistry Cysteine / analogs & derivatives, toxicity Dipeptides / toxicity Glutathione / toxicity Hydrogen-Ion Concentration Mutagenicity Tests Mutagens* Penicillamine / toxicity Salmonella typhimurium / genetics* Sulfhydryl Compounds / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Dipeptides; 0/Mutagens; 0/Sulfhydryl Compounds; 19246-18-5/cysteinylglycine; 3411-58-3/ethyl cysteine; 52-67-5/Penicillamine; 52-90-4/Cysteine; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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