Document Detail

Effect of pH and ammonium ions on mutagenic activity in cooked beef.
MedLine Citation:
PMID:  7306937     Owner:  NLM     Status:  MEDLINE    
Controversy surrounding the extraction procedure commonly used for isolating and concentrating mutagens from foods has resulted in a need for the re-examination of the reported mutagenicity in fried hamburgers. Using a procedure in which Na2SO4 and NaOH are substituted for (NH4)2SO4 and NH4OH respectively, mutagenic activity in extracts of hamburgers fried for 5 min appeared to be unchanged. However, when organic extractions are performed at pH conditions more moderate than those generally employed to isolate mutagens from foods, a 30-50% decrease in mutagenicity is observed.
W T Iwaoka; C A Krone; J J Sullivan; C A Johnson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  12     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1981 May 
Date Detail:
Created Date:  1982-02-25     Completed Date:  1982-02-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  335-41     Citation Subset:  IM    
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MeSH Terms
Ammonia / pharmacology*
Hydrogen-Ion Concentration
Meat / analysis*,  toxicity
Mutagens / isolation & purification*
Reg. No./Substance:
0/Mutagens; 7664-41-7/Ammonia

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