| Effect of p-chlorophenylalanine on thermoregulation in unrestrained rats. | |
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MedLine Citation:
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PMID: 6218760 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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p-Chlorophenylalanine (PCPA), a serotonin depletor, was used to investigate thermoregulation of unrestrained unanesthetized rats exposed to warm (approximately 32 degrees C) and cold (approximately 3 degrees C) environments. PCPA (300 mg/kg, ip) was administered approximately 48-96 h prior to the experimental trials. After 60 min of warm exposure, PCPA-treated rats had a significantly smaller increase in mean tail temperature (3.05 degrees C) and a greater increase in mean core temperature (1.47 degrees C) than did the control rats (6.13 and 1.20 degrees C, respectively) as measured via chronically implanted thermistors. A noninvasive method, infrared photography, was also used to monitor skin temperatures following heat exposure. Changes were qualitatively similar to those seen with thermistors, although differences between control and PCPA-treated groups were not statistically significant. During cold exposure, thermistor measurements indicated that the decrease in mean core temperature of the PCPA-treated rats (0.62 degrees C) did significantly differ from that of the controls (1.11 degrees C), whereas tail temperatures did not. These data confirm other studies implicating serotonin in the thermoregulation of rats. In particular, these results show that in a warm environment, PCPA may alter, albeit subtly, peripheral vasodilation in unrestrained rats. |
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Authors:
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J L Giacchino; E R Schertel; J M Horowitz; B A Horwitz |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 244 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1983 Feb |
Date Detail:
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Created Date: 1983-03-17 Completed Date: 1983-03-17 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R299-302 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation / drug effects* Cold Temperature Fenclonine / pharmacology* Hot Temperature Male Rats Skin Temperature / drug effects |
| Chemical | |
Reg. No./Substance:
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7424-00-2/Fenclonine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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