| Effect of oxygenation on stem-cell therapy for myocardial infarction. | |
| | |
MedLine Citation:
|
PMID: 21445785 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Stem-cell transplantation to treat acute myocardial infarction (MI) is gaining importance as a minimally invasive and potent therapy to replace akinetic scar tissue by viable myocardium. Our recent studies have shown that stem-cell transplantation marginally improvesmyocardial oxygenation in the infarct tissue leading to improvement in cardiac function. The aim of the present study was to determine the effect of hyperbaric oxygen (HBO) treatment on myocardial oxygenation and recovery of function in MI hearts. Fisher-344 rats were subjected to MI by permanently ligating the left-anterior-descending (LAD) coronary artery. The rats were then exposed to 100% O(2) at a pressure of 2 atmospheres for 90 minutes, and the exposure was repeated for 5 days a week for 2 weeks. Adult bone-marrow-derived rat mesenchymal stem cells (MSC, 5x105 cells) were mixed with OxySpin (LiNc- BuO, oxygen sensor) and implanted in the infarct and peri-infarct regions of the heart. M-mode ultrasound echocardiography was performed at baseline and at 2 weeks post-transplantation. The myocardial pO(2) in theMSC+HBOgroup (16.2±2.2 mmHg) was significantly higher when compared to untreated MI (3.8±1.9 mmHg) or MSC (9.8±2.3 mmHg) groups. In addition, there was a significant improvement in cardiac function, increased vessel density, and VEGF expression in MSC+HBO group compared to MSC group (p < 0.05). In conclusion, the results suggested a beneficial effect of HBO administration on stem-cell therapy for MI. |
| | |
Authors:
|
Mahmood Khan; Sarath Meduru; Ramasamy P Pandian; Brian K Rivera; Periannan Kuppusamy |
Related Documents
:
|
11938375 - Combined brucella melitensis and streptococcal viridans endocarditis. 17669765 - Preoperative predictive factors for mortality in acute type a aortic dissection: an ins... 15851635 - Angiotensin-converting enzyme inhibitors and change in aortic valve calcium. 3722255 - Ten-year survival following aortic valve replacement: a multivariate analysis of corona... 21241965 - Effects of short-term anti-inflammatory therapy on endothelial function in patients wit... 19332205 - Screening the population for left ventricular hypertrophy and left ventricular systolic... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Advances in experimental medicine and biology Volume: 915 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2011 |
Date Detail:
|
Created Date: 2011-03-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 175-81 Citation Subset: IM |
Affiliation:
|
Davis Heart and Lung Research Institute, Department of Internal Medicine, The Ohio State University, Columbus, OH, 43210, USA, Mahmood.Khan@osumc.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chronic mild hypoxia ameliorates chronic inflammatory activity in myelin oligodendrocyte glycoprotei...
Next Document: Regulation of cytosolic and mitochondrial oxidation via malate-aspartate shuttle: an observation usi...