| Effect of oxygen-carrying resuscitation fluids on the pharmacokinetics of antipyrine, diazepam, penicillin, and sulfamethazine in rats. | |
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MedLine Citation:
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PMID: 6515128 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of exchange transfusion with an oxygen-carrying resuscitation fluid, Fluosol DA 20% or stroma-free hemoglobin, on the pharmacokinetics of antipyrine, diazepam, penicillin, and sulfamethazine were studied in rats. After transfusion with Fluosol DA 20% or stroma-free hemoglobin the pharmacokinetics of antipyrine, diazepam, and penicillin were unchanged when compared to control animals. After transfusion with Fluosol DA 20%, the t 1/2 of sulfamethazine was increased from 3.15 +/- 0.56 to 7.65 +/- 2.41 hr (p less than 0.05) and the Vd was increased from 60.7 +/- 17.5 to 152 +/- 16 ml (p less than 0.05). In contrast, after transfusion with stroma-free hemoglobin, the AUC of sulfamethazine was decreased from 129 +/- 28 to 80.5 +/- 27.7 micrograms X h X ml-1 (p less than 0.05) and there was an increase in Cl from 12.2 +/- 3.4 to 20.2 +/- 6.0 ml X h-1 (p less than 0.05) and Vd from 60.1 +/- 11.8 to 132 +/- 49 ml (p less than 0.05). The reason for these alterations is not clear. Fluosol DA 20% and stroma-free hemoglobin may alter the acetylation of sulfamethazine. |
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Authors:
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J M Kemner; W R Snodgrass; S E Worley; G R Hodges; S Melethil; C E Hignite; C Tschanz |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Research communications in chemical pathology and pharmacology Volume: 46 ISSN: 0034-5164 ISO Abbreviation: Res. Commun. Chem. Pathol. Pharmacol. Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-02-21 Completed Date: 1985-02-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0244734 Medline TA: Res Commun Chem Pathol Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 381-400 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antipyrine / metabolism* Blood Substitutes* Diazepam / metabolism* Drug Combinations Fluorocarbons Hemoglobins Kinetics Male Penicillins / metabolism* Rats Rats, Inbred Strains Sulfamethazine / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Blood Substitutes; 0/Drug Combinations; 0/Fluorocarbons; 0/Hemoglobins; 0/Penicillins; 439-14-5/Diazepam; 57-68-1/Sulfamethazine; 60-80-0/Antipyrine; 75216-20-5/Fluosol-DA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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