Document Detail


Effect of oxybutynin on the QTc interval in elderly patients with urinary incontinence.
MedLine Citation:
PMID:  8824696     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. Terodiline, an anticholinergic drug with calcium antagonist properties, is associated with QT prolongation and ventricular arrhythmias. It is not known if oxybutynin, a drug with a similar pharmacological profile, causes QT prolongation. ECGs were obtained before and at least 4 weeks after commencement of oxybutynin (mean daily dose 7.6, range 2.5-10 mg), in 21 elderly (mean age 75, range 58-88 years) patients treated for urinary incontinence. Heart rate, (mean +/- s.d.) 74 +/- 11 vs 69 +/- 11 beats min-1, -6 (-13,2), before vs during oxybutynin therapy, mean difference (95% confidence intervals); PR interval, 168 +/- 27 vs 156 +/- 27 ms, -11 (-26,3); QTc 454 +/- 27 vs 447 +/- 31 ms1/2, -9 (-23,5), and QTc dispersion, QTc max-QTc min, 68 +/- 24 vs 63 +/- 26 ms1/2, -1 (-15,14) were all unaltered by oxybutynin therapy. The lack of an effect on resting heart rate suggests that oxybutynin has little anticholinergic action at cardiac M2 receptors at usually administered doses. Oxybutynin therapy is not associated with QTc interval prolongation and is unlikely to produce ventricular arrhythmias.
Authors:
R M Hussain; K Hartigan-Go; S H Thomas; G A Ford
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  41     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-11-14     Completed Date:  1996-11-14     Revised Date:  2009-10-02    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  73-5     Citation Subset:  IM    
Affiliation:
Department of Medicine (Geriatrics), University of Newcastle upon Tyne, UK.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Electrocardiography / drug effects*
Heart Rate / drug effects
Humans
Mandelic Acids / pharmacology*,  therapeutic use
Middle Aged
Parasympatholytics / pharmacology*
Urinary Incontinence / drug therapy*
Chemical
Reg. No./Substance:
0/Mandelic Acids; 0/Parasympatholytics; 5633-20-5/oxybutynin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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