| Effect of oxprenolol and metoprolol on serum lipid concentration. | |
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MedLine Citation:
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PMID: 6734694 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the present study was to evaluate whether a reduction in HDL-cholesterol is peculiar to non cardioselective beta blockers or whether it is also produced by cardioselective beta 1-blockers. 16 patients with primary arterial hypertension on a balanced isocaloric diet were given oxprenolol 120 to 240 mg/day or metoprolol 100 to 200 mg/day in a random cross-over study. No significant change was observed after either treatment in fasting blood glucose, serum total cholesterol and triglycerides. HDL-cholesterol concentration was significantly decreased on metoprolol, from 41 to 36 mg/dl (p less than 0.05), while oxprenolol did not affect it at all. The difference might depend on intrinsic sympathomimetic activity which is possessed by oxprenolol and which metoprolol lacks. |
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Authors:
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L A Ferrara; T Marotta; A Scilla; P Mastranzo; P Strazzullo; M Mancini |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of clinical pharmacology Volume: 26 ISSN: 0031-6970 ISO Abbreviation: Eur. J. Clin. Pharmacol. Publication Date: 1984 |
Date Detail:
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Created Date: 1984-07-27 Completed Date: 1984-07-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1256165 Medline TA: Eur J Clin Pharmacol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 331-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects Cholesterol / blood Female Heart Rate / drug effects Humans Lipids / blood* Male Metoprolol / adverse effects*, therapeutic use Middle Aged Oxprenolol / adverse effects*, therapeutic use Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Triglycerides; 37350-58-6/Metoprolol; 57-88-5/Cholesterol; 6452-71-7/Oxprenolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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