Document Detail


Effect of oxitropium bromide (Ba253) on increased airway resistance induced by various agonists and antigen in the guinea pig.
MedLine Citation:
PMID:  2528646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects of oxitropium bromide (Ba253), which was administered by inhalation, on the resting and stimulus-induced airway resistance were examined in the artificially ventilated guinea pig and compared with those of ipratropium bromide (Sch1000), atropine and isoproterenol. Results obtained were as follows: 1) Ba253 as well as other reference compounds hardly affected the resting resistance. 2) Ba253 strongly and persistently inhibited the acetylcholine (ACh)-induced resistance. Sch1000 caused a similar but relatively weaker inhibition than Ba253. Either atropine or isoproterenol caused only a transient inhibition. 3) The increase in resistance induced by histamine, serotonin, leukotriene D4 or antigen was prevented by Ba253. Atropine, Sch1000 and isoproterenol also inhibited these reactions, but the effects and the duration were generally weaker and shorter than those of Ba253. 4) Repeated inhalations of Ba253 for 7 days did not influence the inhibition of the ACh-induced increase in airway resistance by this drug. However, isoproterenol tended to attenuate the suppression of the resistance by the drug. From these results, it is suggested that Ba253 is a useful inhalant drug for asthma.
Authors:
S W Kohno; H Hashii; K Ogino; H Yamamura; K Ohata
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  50     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-10-26     Completed Date:  1989-10-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  455-66     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Kyoto Pharmaceutical University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acetylcholine / pharmacology
Administration, Inhalation
Airway Resistance / drug effects*
Animals
Antibodies / immunology
Antigens / immunology
Atropine / pharmacology
Evans Blue / diagnostic use
Guinea Pigs
Histamine / pharmacology
Ipratropium / pharmacology
Isoproterenol / pharmacology
Male
Parasympatholytics / administration & dosage,  pharmacology*
Respiration, Artificial
SRS-A / pharmacology
Scopolamine Derivatives / administration & dosage,  pharmacology*
Serotonin / pharmacology
Chemical
Reg. No./Substance:
0/Antibodies; 0/Antigens; 0/Parasympatholytics; 0/SRS-A; 0/Scopolamine Derivatives; 30286-75-0/oxitropium; 314-13-6/Evans Blue; 50-67-9/Serotonin; 51-45-6/Histamine; 51-55-8/Atropine; 51-84-3/Acetylcholine; 60205-81-4/Ipratropium; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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