Document Detail


Effect of oxametacin on endogenous uric acid clearance rate in healthy volunteers.
MedLine Citation:
PMID:  6873149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Oxametacin, a new non steroidal anti-inflammatory compound, with analgesic, antipyretic and anti-inflammatory properties comparable to those of indomethacin, has been claimed to be effective in treatment of acute attacks of gout. The present study comprises an investigation in 8 healthy volunteers of the effect on the endogenous uric acid clearance rate, of oxametacin administered alone or in combination with the conventional hypouricaemic agents benzbromarone or allopurinol. Whether given alone or in combination with these drugs, oxametacin failed to alter the clearance rate of endogenous uric acid. In view of its good tolerance and its possible efficacy in treatment of acute attacks of gout, the present data help to validate use of oxametacin in acute gout.
Authors:
J Broekhuysen; F Deger; J Douchamps; H Ducarne; A Herchuelz; J Polderman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  24     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1983  
Date Detail:
Created Date:  1983-09-09     Completed Date:  1983-09-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  671-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Inflammatory Agents / pharmacology*
Creatinine / metabolism
Female
Humans
Indomethacin / analogs & derivatives*,  pharmacology
Male
Metabolic Clearance Rate / drug effects
Uric Acid / metabolism*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 27035-30-9/oxamethacin; 53-86-1/Indomethacin; 60-27-5/Creatinine; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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